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Volume 149, Issue 3
1 ?/ a% i+ x% c. N3 @On the cover: The combined activity of neurons in the brain generates
) K: s4 o6 |2 s) N/ m6 soscillatory rhythms, or “brain waves,” that can be detected by
) p( d4 N4 W: Q: l$ Nelectroencephalographic recordings. Verret et al. (pp.708–721) found that these 2 R: g/ u* m* E7 B6 q: w" a" M
brain waves, which are represented on the cover by an undulating pattern, are * B' B s+ l5 k( L5 |1 ]& k
altered in mouse model of Alzheimer's disease (AD), and the changes are linked + m4 H. s8 G: u v& I+ X
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
) [- q* Z3 I5 L7 }$ e; uNav1.1 levels specifically in inhibitory interneurons improves oscillatory
7 D5 S* G+ d- A* K) ]! Drhythms and memory in AD mice, offering a new therapeutic approach for $ u8 M! h4 k; f
potentially treating cognitive disorders. The image was created by Arantxa 6 P8 _3 G: m5 g0 y) H8 V$ s; R
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop 4 W! d' j/ W- ~1 c* G/ n
(electronic recreation). m5 c& B' P0 n) b" p4 l0 Q- ?
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