《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
4 E8 W! o2 e1 N- ?On the cover: The combined activity of neurons in the brain generates 0 ^2 P6 s  [, a" l
oscillatory rhythms, or “brain waves,” that can be detected by
- A/ |, g  P% e: y8 |electroencephalographic recordings. Verret et al. (pp.708–721) found that these   r. \1 y% E& i6 ~
brain waves, which are represented on the cover by an undulating pattern, are 9 O; c! _2 t& G, k
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
* \& K' \) F  N/ Cto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
( A+ V. ]# Q$ L/ k; n, sNav1.1 levels specifically in inhibitory interneurons improves oscillatory ! L8 h- L$ l$ ~7 l
rhythms and memory in AD mice, offering a new therapeutic approach for
5 x4 ^% U! p  e3 `* |5 y) E$ hpotentially treating cognitive disorders. The image was created by Arantxa
/ R; v( B6 c' D7 [Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
- x( k3 E! ?( p+ H8 i* @(electronic recreation).
% L: y; ?$ T" l6 N2 F[hide][/hide]

menghy

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eley

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cytobiology

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