《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3% X) v- D1 y: I- `+ t) L
On the cover: The combined activity of neurons in the brain generates
& Z- k/ |! C8 U' k* K9 b! ^% Zoscillatory rhythms, or “brain waves,” that can be detected by " a, k: D0 T& W/ G/ a4 R1 U7 P
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
( z& @* p) {2 w9 t4 c% Tbrain waves, which are represented on the cover by an undulating pattern, are 2 \7 s& x: @, t' W# b  q
altered in mouse model of Alzheimer's disease (AD), and the changes are linked 7 U& ?5 Q- E: `# @. Q. L! W3 C7 |
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 7 h6 s# r6 d6 o9 H; n  s
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory ) j; E7 J9 m; E8 N8 [: C
rhythms and memory in AD mice, offering a new therapeutic approach for * k4 Y3 c, X; i) K, a
potentially treating cognitive disorders. The image was created by Arantxa 2 h9 Y  B& l* y/ |( m
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
4 _& }# x5 H, o(electronic recreation).. C0 O, ^! H* A' U" H  \, v
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cytobiology

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