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( }/ b5 i/ ~( L- q! A6 O1 CVolume 149, Issue 37 x# K b( Q; A- o
On the cover: The combined activity of neurons in the brain generates
; N9 u! ]2 D. J6 u, G# r poscillatory rhythms, or “brain waves,” that can be detected by ( r! m- u3 \4 k9 c+ w
electroencephalographic recordings. Verret et al. (pp.708–721) found that these + }+ @2 M' {* I1 `+ _% _! @; _
brain waves, which are represented on the cover by an undulating pattern, are : P4 Q) O/ c4 V, A
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
/ a/ p( m* w4 H3 T4 s8 ^to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 5 \& }! j$ H/ W, x
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
0 Y- B+ }5 r4 s" B. D8 {6 K% T" @rhythms and memory in AD mice, offering a new therapeutic approach for ; f$ A8 d- B0 r$ _" \" I) P. F
potentially treating cognitive disorders. The image was created by Arantxa
# v {, D2 O) O0 V# uEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
6 S$ B6 Q- U) X. ^; P! I(electronic recreation).- f2 p# N ]! y0 u& p
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