《细胞》[Cell]12年4月27日出版pdf全文

nero1981

4 z: n: `2 c% ]3 h; \0 ~Volume 149, Issue 38 N5 w: M4 G5 U+ @4 z  x
On the cover: The combined activity of neurons in the brain generates
! s, F# t9 W* D+ n0 R8 `oscillatory rhythms, or “brain waves,” that can be detected by
# F! `! u3 \2 y' h3 ]. J. L5 eelectroencephalographic recordings. Verret et al. (pp.708–721) found that these
" E5 D) {+ L0 z( N3 gbrain waves, which are represented on the cover by an undulating pattern, are
5 }! P0 ^5 ^6 m* Zaltered in mouse model of Alzheimer's disease (AD), and the changes are linked 0 x  e8 b* ?: b0 s$ j7 x: b
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
) C0 w+ Y/ q' a7 q: mNav1.1 levels specifically in inhibitory interneurons improves oscillatory
# L# P" ]8 ~$ ~3 j! @$ N% frhythms and memory in AD mice, offering a new therapeutic approach for
! y9 C; W* Y+ x8 A0 Ipotentially treating cognitive disorders. The image was created by Arantxa
  V, p. Y) \; J5 k# U% @Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop - K- A# T' W6 `& j$ d- G
(electronic recreation)." d% @" j7 O9 E6 X* Z3 j& q: W
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menghy

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xiaoheilong

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不倒翁

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eley

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cytobiology

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zorro

回复 cytobiology 的帖子3 J' `  x3 U6 X9 X
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markllq

谢谢
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191225092

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