《细胞》[Cell]12年4月27日出版pdf全文

nero1981

) n: [; J" U. e7 r& U3 S5 }Volume 149, Issue 3+ D: c- c0 o8 I  h* I
On the cover: The combined activity of neurons in the brain generates
+ T3 `( a' i) E9 V- |oscillatory rhythms, or “brain waves,” that can be detected by
! H; `& O1 `: m3 N3 Selectroencephalographic recordings. Verret et al. (pp.708–721) found that these
* j  K+ }8 T+ g! D# v' j. N/ v0 h6 Sbrain waves, which are represented on the cover by an undulating pattern, are
$ e! i3 ~; E2 U- H% u" r( \altered in mouse model of Alzheimer's disease (AD), and the changes are linked 2 K" K- w4 u1 [- {  S! q8 V
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
2 @% _7 ]3 Q4 n/ T$ M, L# jNav1.1 levels specifically in inhibitory interneurons improves oscillatory 7 S  J/ D* b* X/ L7 D
rhythms and memory in AD mice, offering a new therapeutic approach for 4 ~% i# x# U' Z/ _; P5 y
potentially treating cognitive disorders. The image was created by Arantxa
% @" \* @0 B3 t6 ~8 ]Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
5 B/ W) \6 R4 ^# x: x7 w(electronic recreation).
9 ]" q* [; H! d) q/ C8 I[hide][/hide]

menghy

谢谢分享！！

xiaoheilong

看看

不倒翁

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不倒翁

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eley

ding~~~

cytobiology

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zorro

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6 L# r( ~) X7 R2 p+ O+ b0 \) U& l0 V, m/ W$ g5 J8 o8 ~/ w) C
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markllq

谢谢
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191225092

看一看，瞅一瞅。