《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
& m6 k3 n8 k' f3 XOn the cover: The combined activity of neurons in the brain generates 7 K! e. ^8 b6 ?. k1 W( K( A! Y6 E6 I
oscillatory rhythms, or “brain waves,” that can be detected by
0 I# a9 g; V. v, Selectroencephalographic recordings. Verret et al. (pp.708–721) found that these
+ ]7 p5 ~$ [6 x. R3 M0 E: g" nbrain waves, which are represented on the cover by an undulating pattern, are
. ^& _  k7 [7 @: \5 J4 ealtered in mouse model of Alzheimer's disease (AD), and the changes are linked
$ j0 p; j# C3 t3 D* kto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring / J8 H& o9 s$ [+ ~% O! U
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory " R1 C4 u9 f, n* E% v; s
rhythms and memory in AD mice, offering a new therapeutic approach for
) R1 W+ p7 ]# o& y+ V& @potentially treating cognitive disorders. The image was created by Arantxa ' Q+ `4 _5 Z: \( C$ V- E! m
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop - ]" b& B# Z, {3 G
(electronic recreation).
4 f) D* K1 s; y0 O0 z1 M[hide][/hide]

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cytobiology

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