《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3" @5 u7 b9 n. X. G' ?0 p! }
On the cover: The combined activity of neurons in the brain generates
' `5 V0 f  ?  f) C0 i4 voscillatory rhythms, or “brain waves,” that can be detected by $ T, L" \' V' G) a; t/ g
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
) V; K5 x- n# L# l- ^$ o5 }brain waves, which are represented on the cover by an undulating pattern, are
) ^% E5 Z. q7 G! c5 galtered in mouse model of Alzheimer's disease (AD), and the changes are linked
. ?  p  _9 |9 E( f$ J5 zto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
$ O9 m5 y; a# X4 B7 J! c3 ZNav1.1 levels specifically in inhibitory interneurons improves oscillatory - s! j, F" ?. c
rhythms and memory in AD mice, offering a new therapeutic approach for
0 @( n% m  F/ R! npotentially treating cognitive disorders. The image was created by Arantxa - T- N' W% _6 G( V# _9 `
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
% D/ {8 d. J+ D. ^- {(electronic recreation).
* U/ S1 X1 Q# j: y5 Z5 G- ~[hide][/hide]

menghy

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xiaoheilong

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不倒翁

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eley

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cytobiology

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zorro

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markllq

谢谢
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191225092

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