PDF电子书：PROTEIN ENGINEERING （2012）

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PROTEIN ENGINEERING( y3 t, K, e, u; C
Edited by Pravin Kaumaya/ h) a) B! L+ e
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Copyright © 2012 InTech
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Contents1 f( N0 |3 i- `
Preface   IX$ ]2 `& X! Q' H+ C7 r
Chapter 1   Structure-Functional Insight Into Transmembrane Helix Dimerization   1, G/ a2 V1 R$ N& H! g0 v
Eduard V. Bocharov, Konstantin V. Pavlov, Pavel E. Volynsky, Roman G. Efremov and Alexander S.
: q7 i' Z6 c: K* Q2 q1 \: ZArseniev
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: {) L) m! R8 e6 FChapter 2    Protein Engineering Methods and Applications   33
: w' n7 _* g% Z9 X! j' h' PBurcu Turanli-Yildiz, Ceren Alkim and Z. Petek Cakar& s" u# Y8 L& A. b8 l
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Chapter 3   Evolutionary Engineering of Artificial Proteins with Limited Sets of Primitive Amino
) W" h$ ~& C. V& x1 w" J, XAcids   59 Junko Tanaka, Hiroshi Yanagawa and Nobuhide Doi
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! [2 M' {  t" u: L8 ^: a2 q6 ]' AChapter 4   Protein Engineering Applications on Industrially Important Enzymes:/ `5 e7 `2 D" Y* Z
Candida methylica FDH as a Case Study    75: t# c# b. E6 R% _' l
Emel Ordu and Nevin Gül Karagüler
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Chapter 5      Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic 6 t$ H0 c  G8 W0 t3 i
Targeting    99 Jennifer D. Stone, Yiyuan Yin, Min Mo,
& [( T# [3 k1 R( L$ L5 N; W# gK. Scott Weber, David L. Donermeyer,
. a. n& {" }4 ]" K/ M  Z" P8 FPaul M. Allen, Roy A. Mariuzza and David M. Kranz
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Chapter 6    Molecular Evolution Within3 d  i" S0 M& S# k
Protease Family C2, or Calpains    119
/ d0 r4 Q% |  V2 c/ ^* I2 f  }. y4 hLiudmila Lysenko and Nina Nemova
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) o  L- ^- e+ |- }& @: F3 _Chapter 7    FN3 Domain Engineering   145
1 H( c  T0 R+ D! MSteven Jacobs and Karyn O’Neil
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7 r( B/ J  q# IChapter 8    Engineered Derivatives of6 A! b, i* w5 O3 q* k7 X" T; {
Maltose-Binding Protein   163
- P/ Q: ~6 t) k" m2 C3 yPaul D. Riggs
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1 P' \3 V2 D6 B  U& V3 k+ C# DChapter 9      Applications of Bioinformatics and Experimental Methods  to Intrinsic Disorder-Based + U2 P( `) g  ~1 O  o" R1 H
Protein-Protein Interactions    181 Xiaolin Sun, William T. Jones and Vladimir N. Uversky
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9 w3 y) e' A4 Z8 G: bChapter 10     Protein Folding, Binding and Energy Landscape: A Synthesis   207
% E$ V: R0 I) _% EShu-Qun Liu, Yue-Hui Xie, Xing-Lai Ji, Yan Tao, De-Yong Tan, Ke-Qin Zhang and Yun-Xin Fu
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3 y+ v* J3 H2 O) ]  ~Chapter 11    Protein Engineering with Non-Natural Amino Acids   253
& O/ c6 p5 Q+ m& uAijun Wang, Natalie Winblade Nairn, Marcello Marelli and Kenneth Grabstein
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Chapter 12    Generation of Xylose-Fermenting1 [) L% D9 ~+ i4 n3 u
Saccharomyces Cerevisiae by Protein-Engineering    291
1 k. W. k4 ~& oSeiya Watanabe and Keisuke Makino
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Chapter 13   In Silico Engineering of Proteins1 b9 E& U+ u* L; Z  ^& ^
That Recognize Small Molecules    307 Sushil Kumar Mishra, Gabriel Demo, Jaroslav Koča and Michaela
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