PDF电子书：PROTEIN ENGINEERING （2012）

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PROTEIN ENGINEERING% z. H9 e+ g. b3 F1 }# x
Edited by Pravin Kaumaya, h0 y/ b- x) M& K6 q3 h( d5 f
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Copyright © 2012 InTech
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Contents
/ c( o: ?4 X$ |- ?+ y8 b& _; rPreface   IX6 C0 {( `* _; o' \9 P$ [0 q/ ?
Chapter 1   Structure-Functional Insight Into Transmembrane Helix Dimerization   1
$ V' G5 C3 W& l* QEduard V. Bocharov, Konstantin V. Pavlov, Pavel E. Volynsky, Roman G. Efremov and Alexander S.
7 t& F4 L& N2 b* w6 N: w  EArseniev
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Chapter 2    Protein Engineering Methods and Applications   33
; ]+ ~$ j+ Q0 }3 @3 [/ c% l$ MBurcu Turanli-Yildiz, Ceren Alkim and Z. Petek Cakar
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3 l+ k( a; U$ Q+ J1 aChapter 3   Evolutionary Engineering of Artificial Proteins with Limited Sets of Primitive Amino & i) O( s1 @( F# j5 F% ]% u
Acids   59 Junko Tanaka, Hiroshi Yanagawa and Nobuhide Doi& e+ T: q) a: }, R" _
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Chapter 4   Protein Engineering Applications on Industrially Important Enzymes:
/ T3 |* h# X' X3 s1 s2 L% W# RCandida methylica FDH as a Case Study    75' L2 m3 p; a/ w% b8 z7 }
Emel Ordu and Nevin Gül Karagüler" _  B$ ~; L+ R7 h! Z$ `" D
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Chapter 5      Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic
% l1 V& l. J" l  lTargeting    99 Jennifer D. Stone, Yiyuan Yin, Min Mo,% p3 p, F. u  |! T$ n8 e) \! q
K. Scott Weber, David L. Donermeyer,
' A1 e  s% I4 s4 r) n: |6 ?( cPaul M. Allen, Roy A. Mariuzza and David M. Kranz
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  |: g9 ^% }8 g( h$ Y2 i' \Chapter 6    Molecular Evolution Within
7 |! K$ r& J8 K% t0 {) g2 c7 XProtease Family C2, or Calpains    119
2 C/ l7 y* T% Q% B* X- FLiudmila Lysenko and Nina Nemova4 D' |5 u9 A) m- d
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Chapter 7    FN3 Domain Engineering   1457 {: e  D9 u5 P% X2 ~+ Y
Steven Jacobs and Karyn O’Neil
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Chapter 8    Engineered Derivatives of
$ Q+ D' A3 N& j% OMaltose-Binding Protein   163
2 y& E* K; G$ t* Z* i( i9 [Paul D. Riggs' k3 O- Y; k# f& u
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VI     Contents/ F' Z: H# ]$ K# F( t, ]) b

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9 i! V! r; G) u/ K! _" |Chapter 9      Applications of Bioinformatics and Experimental Methods  to Intrinsic Disorder-Based
: \! v: a' {: O' u, d$ h" c: LProtein-Protein Interactions    181 Xiaolin Sun, William T. Jones and Vladimir N. Uversky2 S* R, j2 @8 M  V) P
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Chapter 10     Protein Folding, Binding and Energy Landscape: A Synthesis   207) g) P0 w1 \. o( H
Shu-Qun Liu, Yue-Hui Xie, Xing-Lai Ji, Yan Tao, De-Yong Tan, Ke-Qin Zhang and Yun-Xin Fu9 r5 U2 e5 A" L5 `  [2 g( o  \: ~

6 y; a: H) G; t3 c- Q" F5 uChapter 11    Protein Engineering with Non-Natural Amino Acids   253
1 L# T' {, v/ ?Aijun Wang, Natalie Winblade Nairn, Marcello Marelli and Kenneth Grabstein
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# g: x7 r% {7 N! t6 G+ z, AChapter 12    Generation of Xylose-Fermenting
1 ^8 f! p' H# ]Saccharomyces Cerevisiae by Protein-Engineering    291' {8 j  `% j+ U" A: Q
Seiya Watanabe and Keisuke Makino
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Chapter 13   In Silico Engineering of Proteins" r& M) _+ H7 X- W/ K! U
That Recognize Small Molecules    307 Sushil Kumar Mishra, Gabriel Demo, Jaroslav Koča and Michaela
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