PDF电子书：PROTEIN ENGINEERING （2012）

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PROTEIN ENGINEERING
* i7 q7 K$ T1 c! zEdited by Pravin Kaumaya
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Copyright © 2012 InTech! m0 c" P. @6 A( f# [' S, k; I

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Contents
$ A; f: o% P/ ?, U2 N. u7 c* BPreface   IX7 w$ a9 Y. s: `  X/ v0 K
Chapter 1   Structure-Functional Insight Into Transmembrane Helix Dimerization   1
6 _5 K( c" g' c2 G8 ^Eduard V. Bocharov, Konstantin V. Pavlov, Pavel E. Volynsky, Roman G. Efremov and Alexander S.
5 t, ^/ {2 q. @: D, f9 J* E! `Arseniev
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7 b! Y+ F$ {' Z% d! g9 xChapter 2    Protein Engineering Methods and Applications   33
! h! }$ x+ l4 x0 @- N0 cBurcu Turanli-Yildiz, Ceren Alkim and Z. Petek Cakar
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$ _( ]- x4 Y$ h* j3 f$ a1 o" gChapter 3   Evolutionary Engineering of Artificial Proteins with Limited Sets of Primitive Amino 8 X8 G1 K4 E$ A4 o, w6 J4 `
Acids   59 Junko Tanaka, Hiroshi Yanagawa and Nobuhide Doi, N4 i1 u; \' U; G  _/ h* }
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Chapter 4   Protein Engineering Applications on Industrially Important Enzymes:$ A3 u7 G# R, F6 J
Candida methylica FDH as a Case Study    75
2 K3 b; {$ B; X! K# S- b) ZEmel Ordu and Nevin Gül Karagüler
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Chapter 5      Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic
3 m" U0 p* b: y/ cTargeting    99 Jennifer D. Stone, Yiyuan Yin, Min Mo," K8 @( {* O- V# \" s$ c& ~
K. Scott Weber, David L. Donermeyer,
3 u  r& ]4 s# b, {8 `+ U" uPaul M. Allen, Roy A. Mariuzza and David M. Kranz$ g! T0 y" G- ], f9 M* i+ z
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Chapter 6    Molecular Evolution Within" \% ]( g7 a, q( }/ R8 Q" x
Protease Family C2, or Calpains    1194 Y" `0 h, E+ i2 v
Liudmila Lysenko and Nina Nemova
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Chapter 7    FN3 Domain Engineering   145& l0 O, ]- x0 x+ M: m" k, O
Steven Jacobs and Karyn O’Neil, H2 ?4 T  j6 P

' Z& W( d  k" ^2 f- ~1 ~7 L8 b/ ]$ S  eChapter 8    Engineered Derivatives of) }2 T8 w, j% e8 N
Maltose-Binding Protein   1633 Z- n9 l: ?" H% F. {7 c* v
Paul D. Riggs5 x* C/ m; ^, t, x  p
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VI     Contents
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Chapter 9      Applications of Bioinformatics and Experimental Methods  to Intrinsic Disorder-Based
4 L3 q" h4 P/ p: Y! _, W; GProtein-Protein Interactions    181 Xiaolin Sun, William T. Jones and Vladimir N. Uversky
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8 {3 J0 B# @2 X$ j/ W7 O/ IChapter 10     Protein Folding, Binding and Energy Landscape: A Synthesis   207
9 @8 u+ h! v% w9 vShu-Qun Liu, Yue-Hui Xie, Xing-Lai Ji, Yan Tao, De-Yong Tan, Ke-Qin Zhang and Yun-Xin Fu- q# k2 z) l7 _8 S. I" n' U

1 F' }" f- L. ?; ]Chapter 11    Protein Engineering with Non-Natural Amino Acids   253% w* d% ]- J2 \% k; V
Aijun Wang, Natalie Winblade Nairn, Marcello Marelli and Kenneth Grabstein
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' f! u* v; }/ J" SChapter 12    Generation of Xylose-Fermenting# e- }( \/ ?3 E* X/ j4 J* b7 |  Z: H
Saccharomyces Cerevisiae by Protein-Engineering    291
/ [$ e6 ?5 x- C2 U8 `( V% hSeiya Watanabe and Keisuke Makino
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; X9 c) g! |  I/ [Chapter 13   In Silico Engineering of Proteins5 h: I8 k+ j  a$ y8 i) n9 _# h0 X. o
That Recognize Small Molecules    307 Sushil Kumar Mishra, Gabriel Demo, Jaroslav Koča and Michaela
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