PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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$ G7 e: ?& g6 e7 E0 c( L[hide][/hide]& \$ q" }5 t6 x7 |; m8 L
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ISSN 1064-3745 e-ISSN 1940-60290 G7 D1 _3 Z2 j# h
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
6 l7 k: u* u4 t( p2 U* l8 iDOI 10.1007/978-1-61779-612-81 z5 s# y  C: Y8 ^( m; H$ K
Springer New York Dordrecht Heidelberg London
1 `& s2 ^% a" W6 vLibrary of Congress Control Number: 2012931559
& R; e: ~) v  C+ e' l; k© Springer Science+Business Media, LLC 20125 U% i! r( V! Y! u
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Contents" d- y* d. \& U6 o' l
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ; J6 C+ b" }, L; L( m: l
. . . . . . . . . . . .         v
7 m5 G, K# q' K- a+ bContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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PART I   EARLY EPIGENETIC EVENTS IN CANCER- p' ]( E; C, x' \0 N1 g' f+ I
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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! j- h6 `. }9 Y; p* B  cRamona G. Dumitrescu
$ _% c7 c0 M3 R5 L: w8 G2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . - I/ z! p; {% m3 E; l! n
. .       15
! y, }* t' h' l3 s0 m* i4 `Alok Mishra and Mukesh Verma$ s/ C" h' J; t/ |- v2 i
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES8 b+ l7 c' b4 h" N
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35# C" T* B' g  b2 @( h
Ramona G. Dumitrescu
2 ?5 x7 Z2 a( S: H& `: h* T8 m4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
9 P1 ^7 @+ B: c* `; \! `2 ]5   DNA Methylation in Promoter Region as Biomarkers
" \5 V) r+ z* E. m3 c) ]in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * @) K# x- f; R8 S& H
. . . . .      67
* H+ ~3 `. T4 a9 UMihi Yang and Jong Y. Park$ n( s& x1 d/ ?
6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ) U# U! }" r% }2 E
. . . .     111
$ f% n% t1 r* |6 Z( m0 G" tWun-Jae Kim and Yong-June Kim" b) {: S( T% q/ N/ R" c
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Stefan Deneberg2 C0 a# C: @$ t% L. K
8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor* g& K2 k9 o. D* [( h  s
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155
  `$ r# K$ x7 H$ A3 Y( EQiang Lu, Dehua Ma, and Shuping Zhao
3 N# {6 [" l8 k8 t4 c- s" ?10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Sharad Khare and Mukesh Verma
* r) N3 j+ \' e. m: G7 B11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187( f6 z% M4 _, O3 Z  l+ S( N, l
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
; @8 [* Z9 f/ p6 ^! k8 R; }12   Epigenome and DNA Methylation in Oral. c. F. P" Y' k  ^# F+ L
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
% G9 [5 s% ^  Y3 v) S.    207
0 a5 H) u% \, H6 I, z: EMario Pérez-Sayáns García and Abel García-García6 _0 Q7 K7 n  a& B. {
Mario Pérez-Sayáns García and Abel García-García$ Z+ A8 l/ g' M1 I0 P+ h

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+ I0 ?; H" \- h! Fviii           Contents7 e: j: \! r: D
13   Clinical Implications of Epigenetic Alterations in Human8 h1 f" N7 [! D. _) P
Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     2211 s6 M9 e0 H# t; u
Keiko Shinjo and Yutaka Kondo8 Z0 W4 q; u3 {7 _
14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241) G, s  s) B- V8 G6 ?
Krishna K. Banaudha and Mukesh Verma
( M! d5 `4 E, W15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 q/ j: u2 q5 F& L5 F
. . . .     2538 ^) t: w8 t8 C, U" j. J( O- d
L.M.S. Seeber and P.J. van Diest! I1 R- X, q7 Z# }
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION: i* Y. s: @! e9 r0 }* I, ?. O2 u8 f
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16   DNA Methylation in Pancreatic Cancer: Protocols
! D; T+ R( A- |- S: g9 S- n% jfor the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273& h" X' S" n! {& \9 X
Katja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
5 Z9 o' s" Z, l0 L+ b9 a17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
3 V' w4 ?2 [' O+ L+ wHilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills) w& Y' @* D4 Z( n0 N* `' R. i
18   Screening for miRNA Expression Changes Using Quantitative$ {! ^, C' l$ V4 Y+ |3 z
PCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + J9 i1 J( h4 ?/ N6 l8 I/ L) C: ]7 L% _
. . . .    293
' i% v* y/ ]) Z- y  o9 W* }0 kRichard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills2 g1 ?- O+ Z: q
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 V5 i" B1 i2 w& W" O1 m6 @
.     303
  Z  f6 G8 r! G3 }Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor! t4 h/ {; e9 T- t7 g0 p% t
20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319  s3 m5 \+ i& `" }5 b8 _0 k
Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills" L( R9 B. q  G
21  Detecting DNA Methylation Using the Methylated CpG  A: m# @% ]9 N" o
Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     
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Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER! K- a, l& J4 v, {
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343$ x$ S  ]* ^( f4 I% W. k3 m
Gabriela Riscuta and Ramona G. Dumitrescu' `1 D# C6 R5 P8 G- H
23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
  |: {& j: X7 m( R359
% ]8 G6 P7 ~  M; \0 q# dUnhee Lim and Min-Ae Song
$ f8 W/ f: ~/ L24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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L. Joseph Su
( }- K8 |: [" v# e25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . . / ?. a, S2 ~# S5 P# O
    395
; l! F% S5 t, DSulma I. Mohammed, Sanya Springfield, and Rina Das
0 Z1 O: D3 H1 ]) @6 S& [; a) a7 p26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . .
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  A9 k2 i% u) {+ [Jovanny Zabaleta! T- v/ _# k; T, `

" J$ t9 a% L% k' ]  H7 h2 UContents             ix
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3 s: A1 w6 v+ j' \: D6 nPART V    EPIGENETIC EPIDEMIOLOGY2 C' ^1 J0 p5 q1 M$ R$ ?( J

; r9 s4 f# N  e27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
( W1 w  P8 z) @0 ^. ^7 A* l2 REpigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Kevin Brennan and James M. Flanagan- y' E5 B+ z+ F" A. T" d% X
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    6 O) d7 g, q6 f- l  t) I9 T
467! s  @4 {  ?) a% x8 e! j+ D; A
Mukesh Verma
! [$ s; P6 c  k! i4 ~) }6 LIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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