PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-6029& h. e- a, P4 W% \. H# v
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
& B% D! t% J; ~- f$ DDOI 10.1007/978-1-61779-612-81 h% |( H6 c* i+ Y' y
Springer New York Dordrecht Heidelberg London
! C4 K2 s& A! y9 @1 ZLibrary of Congress Control Number: 2012931559
) P2 w$ _! p, K- O© Springer Science+Business Media, LLC 2012
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Contents2 I/ `* ^1 n  |9 h) V% _
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + y1 m3 H4 m/ q" J; U# `
. . . . . . . . . .        xi
# \: n* f3 U  ]; H6 ^; ]0 r' ~) }( lPART I   EARLY EPIGENETIC EVENTS IN CANCER
: q/ N0 o" k- Y9 v/ k! R1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .       4 n8 z% d0 _. M5 w
  3
" Z9 N8 ?3 P1 x3 f, A2 @Ramona G. Dumitrescu3 G7 _9 F. w5 M3 G: U) u
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Q; v) B/ V( [) x: {& ^
. .       15# E. n5 w$ v1 d; T$ p
Alok Mishra and Mukesh Verma4 I) t  r' M+ p) d
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES
' [2 I9 T; ^0 _4 v* S) p% E/ O3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35
) O* y: H' _% ~; j; yRamona G. Dumitrescu' l! ]/ y) F" F2 A) d" t& ?
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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( ?- q( N' k$ L2 U. Z8 x' T4 k* aWolfgang Goering, Michael Kloth, and Wolfgang A. Schulz5 V- d0 w+ c7 |) z+ s  F
5   DNA Methylation in Promoter Region as Biomarkers
5 b, [- h! ?+ F7 n- y5 Cin Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Mihi Yang and Jong Y. Park; q  z* T" P0 E' P8 ]
6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 s3 N' o) j4 X  s8 _4 \& M% b. . . .     111
: |. g; K) w* BWun-Jae Kim and Yong-June Kim4 R9 z* G  f2 i/ R2 @3 J
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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8 W0 X: o/ x1 [$ ~5 `  fStefan Deneberg
, ~* q& T( u$ {3 h9 ^. T+ q) w8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor
$ t/ \+ Q' a8 d4 n9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155% m1 y$ i. r% D2 W- U
Qiang Lu, Dehua Ma, and Shuping Zhao
3 p3 B1 S$ X, f/ n5 o! r( x9 a10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
8 d5 }0 v8 X$ Z- g/ k. . . . .     177
1 Y. c% K' P3 Z3 ]" i( w( DSharad Khare and Mukesh Verma8 n& I# M" X( u7 H  ?! r/ H
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187( y6 O. D0 L6 J8 L* E1 t8 D8 |
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham' a1 W* N+ l$ B* K1 j" c
12   Epigenome and DNA Methylation in Oral; C3 \* U5 n+ E7 j- |+ v" R" H
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
% M" b3 v4 t2 R  w. Y, x3 ^.    207
1 ]7 o3 u) G' ?! _  RMario Pérez-Sayáns García and Abel García-García* F) y  W2 X7 w1 K4 x! v
Mario Pérez-Sayáns García and Abel García-García
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viii           Contents. w' I& f% H  W+ z
13   Clinical Implications of Epigenetic Alterations in Human
3 m/ p0 S3 y) AThoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221
# F- X* M. r" D0 eKeiko Shinjo and Yutaka Kondo
, g/ J& e8 m: X- B" z; M14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
; y1 a1 e  S7 i, f$ s9 gKrishna K. Banaudha and Mukesh Verma
, J/ v) }& U/ @) ~& V, r- l15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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L.M.S. Seeber and P.J. van Diest
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; `; O4 V6 I* ]- a' e2 o7 WPART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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16   DNA Methylation in Pancreatic Cancer: Protocols3 Q4 a5 e/ L- _/ \6 O  d
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     2730 W4 r% P4 u' V- B1 ~/ C
Katja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
& @5 G3 z$ `( @. }$ E17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
0 [! q+ V3 C+ P* oHilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills9 U: c6 h9 E& O' V5 c/ G3 X
18   Screening for miRNA Expression Changes Using Quantitative
% l7 a% l! \% LPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills
2 U9 Q' z( D9 G5 Y2 K2 S+ W1 i+ G19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 P9 s  ?7 ?8 t; A6 m.     303
! R0 S, V3 @- O1 |) m* ZAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
. y/ H3 t( K. K" f20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
: j/ @% e6 b% ~2 v( EHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills6 d4 T/ M) B6 t% R" ~' S
21  Detecting DNA Methylation Using the Methylated CpG# S& V8 p% a1 j  G! I
Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     - T' Q0 t0 z2 X7 e  P! g
329
" B3 z, r! x$ @# O3 ?Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills
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1 d0 ^) a+ J5 I0 c6 d. @PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
* x+ Y! d1 w, V8 Y5 LGabriela Riscuta and Ramona G. Dumitrescu
& X: b  f  P: f1 K' A4 J: l23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
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Unhee Lim and Min-Ae Song$ G8 |. B+ I) B. _( B
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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L. Joseph Su0 p4 `* ~+ J% g, _4 C! g' E& \8 x
25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . . % m) V7 ^; v5 U
    395
. T# h" a: @4 v; [# K  dSulma I. Mohammed, Sanya Springfield, and Rina Das
* r1 L# [: x7 g  y: o/ G26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . .
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: q1 {# w0 c, k0 E9 TJovanny Zabaleta, x+ `! h. M9 Q% C
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Contents             ix2 F6 l# p7 _4 x& {6 G2 {
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! {7 @- g0 _4 E3 D' z$ T7 N$ wPART V    EPIGENETIC EPIDEMIOLOGY
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27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline$ m# o- }! `3 u
Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ! ]# }" o+ d) k- I9 {/ j
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Kevin Brennan and James M. Flanagan
% V) N9 ]  \/ {  T- l- `7 O28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    % U" \  B% g3 e+ O
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Mukesh Verma
3 F' i3 P; Y( t  b0 ~; O' z3 h0 RIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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