PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-6029" O' V5 d1 ~4 t3 r( Y
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
3 j5 q$ Y! K; G# z8 wDOI 10.1007/978-1-61779-612-8: a9 o4 b" j# y1 h
Springer New York Dordrecht Heidelberg London
% j9 h; Z! |+ w6 K0 J; vLibrary of Congress Control Number: 2012931559
! t' I( n+ }  s4 ?© Springer Science+Business Media, LLC 2012& ]( a2 j+ b9 J. f5 Z/ l6 @

8 `6 `3 p- m, n$ i) \Contents! {. O- e" w2 l( b/ Y1 Z, v5 i) ~
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 I* P5 N, E; _. . . . . . . . . . . .         v
8 n7 P9 k4 v; _/ y& Y& jContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ; M) c5 i' W* _& Z# x' `: L# ?. x9 ~; c
. . . . . . . . . .        xi+ c8 d7 D* F" R# t# B7 I8 g( f
PART I   EARLY EPIGENETIC EVENTS IN CANCER/ t$ v/ I3 m% K& B& c+ |! N5 w: l
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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Ramona G. Dumitrescu) \4 P( }( g3 b6 S$ P. N" F
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 I. o$ \3 f6 y& B. T) l5 m3 L. G9 G' U
. .       15
, P: t, F5 k! @" V8 qAlok Mishra and Mukesh Verma# h# P! p& a! ~) r% `- |
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES8 K, h$ _# K- c
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35) I4 ~/ q4 |& v7 o
Ramona G. Dumitrescu
+ C- }. B; p' Q" D  C* v4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz8 v5 K9 _9 \, i$ i
5   DNA Methylation in Promoter Region as Biomarkers; M/ \* Z! @8 Q  F! T  I
in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 `* [; ~7 e4 l5 P9 B( d. . . . .      67
' Z0 F8 e. _# F8 Z& AMihi Yang and Jong Y. Park" z; ^9 Y+ [" d9 n9 [+ B3 z. W
6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 Y; D) G2 Q; e1 a
. . . .     111
. o" [; H& r- D& ~/ kWun-Jae Kim and Yong-June Kim2 L% Y# n: c+ d. d- g) m
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
+ q+ ~  f  m- l' W  `0 R. .    119
+ K7 M* s+ F7 m7 _  r% w* w5 O& P+ s# tStefan Deneberg) a' ?9 I( h, C, g; _
8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor
6 @9 Z  ^: @" ?: m9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    1552 Q9 L( V) H5 U8 y( P1 ^4 L( D& ]
Qiang Lu, Dehua Ma, and Shuping Zhao
/ i: a+ i9 G1 r2 l5 d10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 L9 c4 z, U% z  p7 g5 x% w, N" N
. . . . .     1770 H8 N) M: F0 d/ I/ s! o; u
Sharad Khare and Mukesh Verma
: Q4 j  j  O8 ~, [# t7 h11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
6 U6 ~" V6 U" @( l% Z, }Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
. e+ U4 l  U5 Q* W2 n12   Epigenome and DNA Methylation in Oral2 M; }5 A# ^5 ?7 s3 _0 y
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. L# k" `" \; w7 o.    207
9 R4 T; `& |8 i) \/ lMario Pérez-Sayáns García and Abel García-García
5 c! r. P% L' r$ P0 A3 b. qMario Pérez-Sayáns García and Abel García-García& m" H; L' W' c$ S: V0 r
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viii           Contents) `0 i1 E1 ]7 Y% |  e" v
13   Clinical Implications of Epigenetic Alterations in Human( X! K5 n/ A* v2 j( g! C7 a  k+ T1 W
Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221
; i% E' k) f% b: M  x( D0 T* bKeiko Shinjo and Yutaka Kondo
. H' @& h: {6 E9 u' Q+ _14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
/ V% `* f; g4 S7 N5 j! D! |Krishna K. Banaudha and Mukesh Verma+ ]5 a) C6 H, m5 F2 X1 ^
15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
8 a  G4 D, q% c" s  Q  L* p+ z. . . .     253: U; M# p& E: M- Z6 T# h1 n
L.M.S. Seeber and P.J. van Diest
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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16   DNA Methylation in Pancreatic Cancer: Protocols& Z$ ^( j) [! _; G8 f$ b
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
8 b4 L. j, a" K2 W. CKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky# D' H7 {' L! O+ w/ W
17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281. G; x9 V+ C" h, ^! i, ^5 b* G
Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills* ?4 S& u* v- x2 M
18   Screening for miRNA Expression Changes Using Quantitative( f7 l) ]: z4 v) f
PCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * G$ {1 h3 K& G7 T8 X
. . . .    293
- l  b$ e7 R/ J, xRichard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills
$ c% E( M% t5 s$ u* k. X- |19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 G2 L3 n. |. \$ H7 K
.     303
0 I* M7 Z& v1 T  iAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
, Z9 {" s; v- P. n" I8 a$ z) a20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319& G& y6 r! u& [
Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills7 F0 J7 a& @! R1 u  e9 S% e0 {
21  Detecting DNA Methylation Using the Methylated CpG/ t# P# u$ j% V4 N9 S$ E
Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     ) c& C7 c4 J/ c" L$ I9 v9 X
329
& w, [- `2 o% KHilary A.A. Colyer, Margaret Dellett, and Ken I. Mills- e8 p* n' B2 B3 s. R4 J0 N
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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$ ^  C. B8 _5 e% H  Z! H! ?2 I/ z22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343& ^, V* |% g. j8 |2 Q- w1 u
Gabriela Riscuta and Ramona G. Dumitrescu
5 h4 r  d# ^* _3 D23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     ! c: M* N. u2 D* I7 @2 a" I
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Unhee Lim and Min-Ae Song9 `8 ?" [; {# _* _; Q. K
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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L. Joseph Su, V' Q) H8 A9 @' e2 Q
25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
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Sulma I. Mohammed, Sanya Springfield, and Rina Das; a( b! J! T* T- P5 U
26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . .
" H8 p) l5 A0 T% q5 h. .     411
4 R$ V) M: M0 Z8 dJovanny Zabaleta0 ]% U4 k5 w8 I+ _6 K0 a) |; ]. o8 p
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Contents             ix- ?2 p+ d6 T' l' N9 u

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/ |. L* D/ \' |+ `% P; U. WPART V    EPIGENETIC EPIDEMIOLOGY
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27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
# d  f+ t3 r. ], r  fEpigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " K9 F2 ]+ v  k4 K' A, Y* \
. . . . .    439/ T3 _: }5 _0 E, u
Kevin Brennan and James M. Flanagan4 m/ ]) i% q, c
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .   
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Mukesh Verma
' z8 Y- ^# h8 }+ k9 W' ^9 h+ D0 }Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
% p8 r8 H  g  Z3 P' _4 n7 P# H. . . . . . . . . . . .     481, M) V/ W/ t6 i7 f7 Q; E

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