《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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Volume 153, Issue 1
2 H; }. i/ ]' r! c7 _) ZOn the cover: The kind of food an organism consumes has a broad reaching ) S5 V4 v. E. c+ K
impact on its development, behavior, and lifespan. In this issue, two $ L; I+ R( E) N" c& r
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore & J6 d' v: T( b) t
the effects of diet on these life-history traits in the nematode C. 0 B+ ]8 Q" |# l( Z+ J% O
elegans. Combining nutrigenomics and network analyses, they find that ; ^: V7 u5 F/ G8 G
different diets affect traits via distinct mechanisms. The response to diet is 4 n, c2 d3 @+ m; _  U) g
coupled to metabolic changes, and disruptions of some of these specific
. \  M2 o, m' P( Qmetabolic pathways correspond to inborn errors of metabolism in humans. The ( z& e/ }4 ~! a) {! n) G
cover features a “native-art-inspired abstraction” of a worm eating a bacterial
4 }2 A- T) }0 `7 u3 X' Kdiet and illustrates the interconnectedness between diet, nuclear gene + [4 [1 q; q! D2 ]- H9 B0 H
regulatory networks, mitochondrial networks, and their effects on life-history 0 M3 J6 b) @. L
traits such as development and brood size. Cover art by Lesley T. MacNeil.6 {% g- A* N1 E0 @* e3 Y

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