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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑
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Volume 153, Issue 12 V- c5 Z: E$ Y! K: [
On the cover: The kind of food an organism consumes has a broad reaching
$ t3 J1 |3 \9 ?/ A P! T; qimpact on its development, behavior, and lifespan. In this issue, two
& f0 Y/ d8 Z5 G7 bpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore / L* D- e* {( _3 {* B: M
the effects of diet on these life-history traits in the nematode C.
( {5 M5 B( I# x$ O: yelegans. Combining nutrigenomics and network analyses, they find that 5 }# c" y% n8 S% G! w+ y5 q- Q# c% _
different diets affect traits via distinct mechanisms. The response to diet is
# M% C+ m* [2 u8 U! d/ ]coupled to metabolic changes, and disruptions of some of these specific + I; Z# J- P9 R5 u" q2 |0 N! p
metabolic pathways correspond to inborn errors of metabolism in humans. The % A9 K: n' r k F
cover features a “native-art-inspired abstraction” of a worm eating a bacterial ( P' {4 t2 t; t+ Z1 Z3 {
diet and illustrates the interconnectedness between diet, nuclear gene 9 h. r3 m$ O/ |
regulatory networks, mitochondrial networks, and their effects on life-history
, X/ z* G |- Q# \# B0 v, Ptraits such as development and brood size. Cover art by Lesley T. MacNeil.
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发表于 2013-3-29 13:31
发表于 2013-3-29 23:38
