《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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. C0 s; v  l5 z5 ], y4 C4 bVolume 153, Issue 1
0 S6 E, w* l" C) Q/ mOn the cover: The kind of food an organism consumes has a broad reaching % j; B# w! r- E; v& x
impact on its development, behavior, and lifespan. In this issue, two 7 R( e0 ]. ?: @! G) g, K6 u- V
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
, \- `/ v+ f* E7 a( ~9 qthe effects of diet on these life-history traits in the nematode C. 6 g7 g6 c3 e/ B! E" b
elegans. Combining nutrigenomics and network analyses, they find that ( i# u: r. @" f1 _# W
different diets affect traits via distinct mechanisms. The response to diet is
3 \2 B6 u8 r' p  B+ vcoupled to metabolic changes, and disruptions of some of these specific " S# U: p  h: q& [
metabolic pathways correspond to inborn errors of metabolism in humans. The 6 g+ q" t0 D# Y5 L" v: C
cover features a “native-art-inspired abstraction” of a worm eating a bacterial
2 [- W7 \5 b8 F2 m8 \diet and illustrates the interconnectedness between diet, nuclear gene ( ~- Z: p, T7 p  N4 N# Q
regulatory networks, mitochondrial networks, and their effects on life-history
; Q! S) N$ }  {/ A3 Q+ S8 {traits such as development and brood size. Cover art by Lesley T. MacNeil.
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