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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑 ( h' J, N* f9 V/ i3 b- ]7 I0 Z
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) v2 Q2 `% P" Q6 gVolume 153, Issue 13 S. O, n3 L0 s: \5 O
On the cover: The kind of food an organism consumes has a broad reaching
/ u! H4 j. D/ o! N6 Fimpact on its development, behavior, and lifespan. In this issue, two
2 i( g9 R9 @! t$ `$ t7 k* O. Kpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore . L8 V# `" J5 u. M
the effects of diet on these life-history traits in the nematode C. A, H$ C ?; F& h
elegans. Combining nutrigenomics and network analyses, they find that ! q7 N' w/ E- c" ?! ^8 W
different diets affect traits via distinct mechanisms. The response to diet is
0 V7 r+ W+ Y$ k1 x' |" Rcoupled to metabolic changes, and disruptions of some of these specific ! `! }) U6 b2 V8 x9 S
metabolic pathways correspond to inborn errors of metabolism in humans. The 5 |; {" k/ I; n; B9 h% N/ U/ e
cover features a “native-art-inspired abstraction” of a worm eating a bacterial
$ J. M+ `/ P! c) d* T9 f; L2 U' ediet and illustrates the interconnectedness between diet, nuclear gene : @# v! f# |6 |" B
regulatory networks, mitochondrial networks, and their effects on life-history
' u: _7 U1 |% ^* xtraits such as development and brood size. Cover art by Lesley T. MacNeil.# R$ ]6 j8 J: |' W
# x; ^9 o1 s0 w) m
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