《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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Volume 153, Issue 17 h" {2 F( N+ ?; ?" ?& V
On the cover: The kind of food an organism consumes has a broad reaching
. W8 ~. i" @/ |3 oimpact on its development, behavior, and lifespan. In this issue, two
8 B  F& z' |7 K- g2 c" |papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore 9 t' N7 d$ N4 Y- @5 n6 q, o
the effects of diet on these life-history traits in the nematode C. 5 n* i, E$ ?$ [2 \- F' S/ A) r
elegans. Combining nutrigenomics and network analyses, they find that ) q0 A: l. \* v: R7 y9 p, o, e% v& I1 J& s
different diets affect traits via distinct mechanisms. The response to diet is
; _* t" c; ?4 ^coupled to metabolic changes, and disruptions of some of these specific
) Y* I6 }% i2 G$ k4 @metabolic pathways correspond to inborn errors of metabolism in humans. The + h# ~3 ^+ ~# \: w$ ]. K6 R* X9 q
cover features a “native-art-inspired abstraction” of a worm eating a bacterial
' A* \; X0 I! t9 C5 |diet and illustrates the interconnectedness between diet, nuclear gene
7 D8 k! D( |0 i4 ?* h6 O- lregulatory networks, mitochondrial networks, and their effects on life-history
  \5 H; R' j8 o1 q( N7 gtraits such as development and brood size. Cover art by Lesley T. MacNeil.6 u7 P: U! {. {, q3 d
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