《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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Volume 153, Issue 11 P. s1 A3 y* `+ }- K+ j
On the cover: The kind of food an organism consumes has a broad reaching
4 C2 t* d- m) P1 y( E; rimpact on its development, behavior, and lifespan. In this issue, two   ?  a% w8 m3 O: T; R2 i5 S0 s
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
7 W+ y% _# W- v& W6 j( |6 Tthe effects of diet on these life-history traits in the nematode C.
7 W: E! f4 g$ Y5 U1 ^( T' helegans. Combining nutrigenomics and network analyses, they find that
3 m; X/ K: r$ d" U) B; `different diets affect traits via distinct mechanisms. The response to diet is 1 h" z, A, ?2 e
coupled to metabolic changes, and disruptions of some of these specific
/ B; d+ ?  P0 F! \' Z1 Gmetabolic pathways correspond to inborn errors of metabolism in humans. The
, n" H1 x  N& Scover features a “native-art-inspired abstraction” of a worm eating a bacterial + S4 U/ d  t* b0 K
diet and illustrates the interconnectedness between diet, nuclear gene
6 O: F: T) o$ l7 c4 uregulatory networks, mitochondrial networks, and their effects on life-history 1 i+ P- E& A* y0 @6 J
traits such as development and brood size. Cover art by Lesley T. MacNeil.+ c$ T# q9 \; T! m. D- J4 |1 B

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