《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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7 V5 d6 r" u; V: Q2 n  o1 R% R9 WVolume 153, Issue 1
! _! t+ |! `3 O& H) g- ]7 zOn the cover: The kind of food an organism consumes has a broad reaching - X6 y! |' L; ^& I- O4 \1 E
impact on its development, behavior, and lifespan. In this issue, two ! j5 g/ }4 F9 n+ }5 \/ D* E
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
; }. C3 U5 h& D# l4 kthe effects of diet on these life-history traits in the nematode C. , X: }9 t4 k/ |# e
elegans. Combining nutrigenomics and network analyses, they find that
* o' J4 d0 g$ c# _% P. U+ N' Adifferent diets affect traits via distinct mechanisms. The response to diet is - T* _, b, p9 O
coupled to metabolic changes, and disruptions of some of these specific
  M) d6 o" n% t# ~* T) ]metabolic pathways correspond to inborn errors of metabolism in humans. The
8 X1 N" U% P/ L1 ^) Z. Zcover features a “native-art-inspired abstraction” of a worm eating a bacterial 6 u" _, ]5 p" ~0 Z: B
diet and illustrates the interconnectedness between diet, nuclear gene + e; u# n5 M$ [3 D$ d- h, T
regulatory networks, mitochondrial networks, and their effects on life-history ' v8 L- K% ^7 o4 }
traits such as development and brood size. Cover art by Lesley T. MacNeil.# L. `7 t9 r$ {

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