《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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- z! d3 |% C; k- f) j/ F7 [Volume 153, Issue 1
/ L9 Q6 Q8 m7 P3 UOn the cover: The kind of food an organism consumes has a broad reaching
6 C7 L6 m0 J5 A% i6 w* ]impact on its development, behavior, and lifespan. In this issue, two ( Z) @$ {$ L( v" o1 a3 ?$ \
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
8 c) N- S2 T& w9 f/ gthe effects of diet on these life-history traits in the nematode C. $ n7 R4 ~( Q+ K" `
elegans. Combining nutrigenomics and network analyses, they find that
  B; C4 X7 E* N& fdifferent diets affect traits via distinct mechanisms. The response to diet is 2 x! T! ^8 A$ m# t
coupled to metabolic changes, and disruptions of some of these specific
3 i& Q+ K  j3 Pmetabolic pathways correspond to inborn errors of metabolism in humans. The ! ?/ a- _2 e# M4 c5 E
cover features a “native-art-inspired abstraction” of a worm eating a bacterial 7 S: g; z5 I9 W' A
diet and illustrates the interconnectedness between diet, nuclear gene
, o+ A$ C* F2 l) _- X7 H9 }, Vregulatory networks, mitochondrial networks, and their effects on life-history
  h0 j  U# }  ?2 ztraits such as development and brood size. Cover art by Lesley T. MacNeil.9 Z" E) s8 o( Q) p
6 b) w  L' L) l/ W5 D; z1 e

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