《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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Volume 153, Issue 1
1 G- A6 `2 ^6 M# f" ^: o6 p9 bOn the cover: The kind of food an organism consumes has a broad reaching 4 U6 ^3 Q- p( ?( B6 Q5 L! }
impact on its development, behavior, and lifespan. In this issue, two
7 }# U  M1 B6 |8 i+ fpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore 0 W2 g" v. R; B! D
the effects of diet on these life-history traits in the nematode C.
9 b8 i2 [' K6 s8 t( B$ [& {elegans. Combining nutrigenomics and network analyses, they find that 4 y$ }, a% D9 M5 |7 ?
different diets affect traits via distinct mechanisms. The response to diet is % }( c0 d9 A& K& w& U+ t( f
coupled to metabolic changes, and disruptions of some of these specific 6 z, K# z! q6 \7 V
metabolic pathways correspond to inborn errors of metabolism in humans. The
" F! \+ ~, ^. E: J  xcover features a “native-art-inspired abstraction” of a worm eating a bacterial
8 N8 s2 ?) i1 ~- qdiet and illustrates the interconnectedness between diet, nuclear gene
: P& `: D+ ?; h& ]9 H( y9 tregulatory networks, mitochondrial networks, and their effects on life-history
" z  Y+ x( z9 ~2 btraits such as development and brood size. Cover art by Lesley T. MacNeil.
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