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6 k$ j: Q7 h' T0 ]& J
) L/ y/ s; H% v8 g* RVolume 25, Issue 3On the cover:
! J& ?" H" o! `# n6 A) FEpidermal growth factor (EGF) induces fast and efficient mitotic progression, 5 C3 h( m* Z1 [1 K2 u# C# H2 J1 z }
particularly in cancer cells, by accelerating centrosome separation. Thus, a - W. p) U3 [3 S i" {9 M+ T
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a - z- k/ D) Y5 P2 x/ h
cell left untreated (right path), as visualized by confocal microscopy.
5 g/ }5 t! q$ mH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear % X6 r3 E" X# z& e3 [, W# E
envelope. For more information on the effect of EGF on centrosome separation and + N8 z- ]/ N1 \6 [/ g
mitotic progress, and on how this may relate to cancer therapeutic strategies, ( K' \! r% C( o6 P7 l! I) t% J
see Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
