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Volume 25, Issue 3On the cover:
/ _5 ?7 |' A0 tEpidermal growth factor (EGF) induces fast and efficient mitotic progression, 2 R6 ?0 e+ U$ b( E. C
particularly in cancer cells, by accelerating centrosome separation. Thus, a 1 b* K) Z. v1 j/ S; E
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a * x, F. p9 L9 Y+ C$ u6 @6 l
cell left untreated (right path), as visualized by confocal microscopy. ( I2 d% F7 X- ], Y" e* ^9 k
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
! }2 v% w5 t. Q$ F qenvelope. For more information on the effect of EGF on centrosome separation and $ f3 M2 ]$ O& J5 y! A8 X- e
mitotic progress, and on how this may relate to cancer therapeutic strategies, + u) H( b) P, e8 ?
see Mardin et al., pp. 229–240.- {' i1 n0 L7 x5 ]. E! T
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
