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; {6 k- m* H/ h3 D; W $ D j' t, N7 }' p6 L$ M5 S0 J
Volume 25, Issue 3On the cover:
# ?5 E# `$ N8 \, M+ O; }Epidermal growth factor (EGF) induces fast and efficient mitotic progression,
! m- l% A4 c! Z; d+ b b8 Zparticularly in cancer cells, by accelerating centrosome separation. Thus, a
: n l) E. {6 o; }; q. [% PHeLa cell treated with EGF proceeds faster through mitosis (left path) than a 1 r6 W7 P3 G) L+ Y! S8 o/ w. H
cell left untreated (right path), as visualized by confocal microscopy. " _7 S8 |: h2 e! {2 \1 h/ |
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear - a) W( z# O& u4 h% u" U2 O( F( E( Y
envelope. For more information on the effect of EGF on centrosome separation and
# @9 V- h" w$ w7 K/ g/ }mitotic progress, and on how this may relate to cancer therapeutic strategies, ) g8 G) A |8 p
see Mardin et al., pp. 229–240.2 \# Y! w, N- Q* V
5 ?: A/ ]7 ]7 V: N) X+ R
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
