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5 w% P' v' g& q4 M$ H! CVolume 25, Issue 3On the cover:
2 s* N6 U+ H2 R$ d) D" L7 @Epidermal growth factor (EGF) induces fast and efficient mitotic progression, ! B" z# A& v) p
particularly in cancer cells, by accelerating centrosome separation. Thus, a
) {- a! K: }/ b, h5 hHeLa cell treated with EGF proceeds faster through mitosis (left path) than a 0 h# A' @8 q, U7 H; j, m! z
cell left untreated (right path), as visualized by confocal microscopy.
" ]. y: e9 q& N8 cH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear # w' A% s8 g9 a! [, i
envelope. For more information on the effect of EGF on centrosome separation and ! P) E- n# A9 H# I5 O& O
mitotic progress, and on how this may relate to cancer therapeutic strategies,
, h: h: b/ y2 c' _- u! H% |see Mardin et al., pp. 229–240.$ \$ o) r' w- k4 A+ }! L
. `2 m8 l( i& x2 F& g/ l0 S1 `/ D |
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
