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7 K, X3 B m1 TVolume 25, Issue 3On the cover: 7 J. `; h) w T# {
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, 3 O# n; |; G$ ]- j
particularly in cancer cells, by accelerating centrosome separation. Thus, a
; W& q5 Q! K' nHeLa cell treated with EGF proceeds faster through mitosis (left path) than a ' f# p8 |0 d+ Y( p- O C4 b
cell left untreated (right path), as visualized by confocal microscopy. 3 E# u. W+ N5 H1 T( U8 C9 ^
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear ) Q$ d8 B/ ?' P7 k4 Z2 L
envelope. For more information on the effect of EGF on centrosome separation and
; s1 k& [: S$ {1 umitotic progress, and on how this may relate to cancer therapeutic strategies, - l9 k/ A7 c1 a- P
see Mardin et al., pp. 229–240.
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
