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Volume 78, Issue 4On the cover: Neural networks control
) P, a9 W" V- G3 A. B0 Ointrinsic encoding of the circadian clock. Circadian pacemaking in the
x1 q+ F7 r, l5 t$ `3 L. Qsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and % V9 z6 n+ X( `( V( ]; B' s- T
intercellular properties, with the latter still poorly understood. In this issue
6 |/ P7 h7 U2 N9 N7 [4 e* Oof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level " h( }. m8 K& O
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in 7 |! c" {, x5 d u! H( H
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
/ j0 y+ u# L) L* X7 o) ~the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
W; }5 D" C- x6 |, g! f: Q& ^: v, nconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna 3 O) ?8 U4 M, j- H" Q9 r
Westmoreland.0 z% x; y( @1 g% R
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发表于 2013-5-23 23:46
