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Volume 78, Issue 4On the cover: Neural networks control
+ h4 C+ i: R0 K7 y+ L. G7 wintrinsic encoding of the circadian clock. Circadian pacemaking in the
: x. g! ~# |5 A9 l Tsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
$ [2 o. I" z' f2 m" N1 Y. ?intercellular properties, with the latter still poorly understood. In this issue
3 y' n2 ^& v7 `$ ~of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
/ v1 H, C" ^$ L+ b& fencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in 7 E1 C% N/ {5 e' i; W- j) n
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
6 }; u4 |+ I6 d+ ]' Ithe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic ) Q! W: x4 Q3 R0 T; L
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
2 s5 `( n& K9 o: H0 YWestmoreland.5 p7 |4 i8 V1 G7 G# g0 L; l1 a
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发表于 2013-5-23 23:46
