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Volume 78, Issue 4On the cover: Neural networks control
% G5 ?+ D% ~4 \1 ?. S$ ~( dintrinsic encoding of the circadian clock. Circadian pacemaking in the
) g- u% n5 A# Y+ Dsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and + l7 J( s2 G% R! k( _( d1 R' B4 I
intercellular properties, with the latter still poorly understood. In this issue
/ H; p* \: q) x4 `( a/ u8 Rof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
: c0 [! g! g3 ]7 C( p# tencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
' _. ]8 q; S/ s3 L: C# _7 D/ B: irestricted SCN neuronal subpopulations reprograms encoding of circadian time by ) Q: k" z2 N+ [3 t" d1 y1 z2 c
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic 5 H) L; F/ U. ]0 g# d% v5 c
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
# x& U# J0 e/ d! X E4 F9 v: rWestmoreland.
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发表于 2013-5-23 23:46
