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Volume 78, Issue 4On the cover: Neural networks control
! Z$ ^/ l) d2 Z. x% M) a5 _intrinsic encoding of the circadian clock. Circadian pacemaking in the ( V# B4 F0 K/ T! f+ e- t" B
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
) }9 \ B/ m5 M5 Zintercellular properties, with the latter still poorly understood. In this issue
% X0 x9 ~. {6 W3 E5 Wof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level ' H& x! c, A$ i
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
) x7 z6 {5 h& Y( h6 |; B# hrestricted SCN neuronal subpopulations reprograms encoding of circadian time by ! e3 @- R$ j" [' m3 @* T% C% ]
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic " n z1 v: `/ L/ P
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna 1 u/ e" o; \7 a+ a& i/ ?
Westmoreland.. ^2 t- [# s @ p+ x! k1 M2 E
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发表于 2013-5-23 23:46
