2013-5-22 Neuron

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4 g4 U! h7 E8 |Volume 78, Issue 4On the cover: Neural networks control ) }  i# L, G2 G4 q- m" N
intrinsic encoding of the circadian clock. Circadian pacemaking in the
- p- t0 g+ C8 q7 Z3 l+ P; _7 Rsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 4 p& D+ w2 e2 Y8 H
intercellular properties, with the latter still poorly understood. In this issue
' D9 \8 ~6 J" W, ]8 _4 m- |of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
% V' e2 g( p; U. a6 e& yencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in " [1 e( N% |+ W, L2 g' w' v) U
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
$ I- K# B1 M& x$ ?2 _9 B% cthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
; q: P8 L) q5 z! Cconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
' w6 V: p6 b# V! Y; q' R9 }% h2 oWestmoreland.
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