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$ z3 j6 U9 b% v# ^1 Q- @+ p \. fVolume 78, Issue 4On the cover: Neural networks control % h9 D$ @$ z$ z( K& p( k T
intrinsic encoding of the circadian clock. Circadian pacemaking in the ' k4 T! h9 s U9 d6 X! S
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
7 n: j+ t: Y. `0 E" ~intercellular properties, with the latter still poorly understood. In this issue % w4 B6 `( j- x6 `9 @4 I3 s" p
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level * k! z, ~6 X0 }2 K- A
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in ) G. T) q* N+ o7 V1 D
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
5 ^2 G/ J& s3 `0 Z! A2 ?4 Uthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
* F [# S' S) _! ], Wconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
, o, b/ U' o lWestmoreland.
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发表于 2013-5-23 23:46
