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% B" l$ Q$ e) HVolume 78, Issue 4On the cover: Neural networks control 4 K. i( r' \2 G0 w0 i4 w* g
intrinsic encoding of the circadian clock. Circadian pacemaking in the " M) @2 p1 Q2 E! i5 J
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 1 U' _% V2 w7 i; \" J9 f
intercellular properties, with the latter still poorly understood. In this issue
( O7 I( y0 r2 G0 @' c+ nof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
: K" ~( h s$ _1 Lencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in ' x- a' Y5 |* W# H
restricted SCN neuronal subpopulations reprograms encoding of circadian time by 6 B. k5 Q1 `3 ?( U$ }& l3 W" S
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic 7 r4 t+ q( E4 F& Z, X+ @5 |
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
3 U* Q3 p7 h, ?- i3 cWestmoreland.9 V5 V! n4 V2 b# v6 W+ U2 M$ l; j' x
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发表于 2013-5-23 23:46
