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Volume 78, Issue 4On the cover: Neural networks control 4 I1 |5 d4 |$ m1 ^' I5 P
intrinsic encoding of the circadian clock. Circadian pacemaking in the
, u2 a3 g( M5 A5 T- g% j. m, csuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and j/ u% D" d, g. }, q+ H
intercellular properties, with the latter still poorly understood. In this issue
7 m- F0 @+ @6 I& x/ b* nof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
4 j8 O& v* l1 |4 X' p# t; oencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
; r$ `+ Y& O0 j/ i7 ?, Trestricted SCN neuronal subpopulations reprograms encoding of circadian time by
. k( A! M) W: W7 v4 Tthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
- H, r" Z- q' B. ^6 }connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
6 G5 w: {8 Z. r! K8 ~# C) B+ mWestmoreland.$ V/ N( Q3 H! b" y; R! I9 O9 [
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发表于 2013-5-23 23:46
