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" Q. E. _. I; ?. w$ O9 G
4 S: N8 N$ w, h1 _& R1 v. n2 BVolume 78, Issue 4On the cover: Neural networks control ( Q! w! k4 H0 H2 v8 ^2 I
intrinsic encoding of the circadian clock. Circadian pacemaking in the % y" q' \8 W) q; U) e( I( R; v
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
4 L* X' }: z" P/ Z3 wintercellular properties, with the latter still poorly understood. In this issue . F. x" T" h" N( q
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level * [' O2 O U i! k
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
& E1 f+ F* U3 ] Z: y& h, @restricted SCN neuronal subpopulations reprograms encoding of circadian time by 2 h4 j8 v2 h6 M9 H- S
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
' F# ?8 H/ t) g! m0 h1 y1 ]connectivity. Concept by Marco Brancaccio; cover illustration by Joanna / c% y. t5 O9 I/ V) A& o; W
Westmoreland., U- ^7 K9 w4 \5 v# {" m. {) M
4 \; X! R# J* q2 X. E( F/ z- k
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发表于 2013-5-23 23:46
