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) U Q6 V1 p2 i7 |5 GVolume 78, Issue 4On the cover: Neural networks control ( i0 q: ` x9 u. t
intrinsic encoding of the circadian clock. Circadian pacemaking in the
) V( J4 ~/ g* _$ M% Z5 Rsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and . Q+ X6 [6 `# G
intercellular properties, with the latter still poorly understood. In this issue
( R# M& p" r& V$ s, wof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level ) \6 {" f J. B0 w3 E' H" a/ R# m7 O
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in . G( C7 `3 L2 A3 Y# L8 q% g
restricted SCN neuronal subpopulations reprograms encoding of circadian time by / v5 B* K" ?" w9 M, r; }; y+ _
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
/ C0 j6 D* Z1 b) `/ }connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
& A9 b, Z q D$ u1 S) tWestmoreland.) z& l& s" @! \5 `- v2 T
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发表于 2013-5-23 23:46
