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Volume 78, Issue 4On the cover: Neural networks control ; y& B' \/ X) v! R* g
intrinsic encoding of the circadian clock. Circadian pacemaking in the ) G" |9 J( `; ~# L' e: h l: p
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and ! ^3 |; b, \8 E; I! R
intercellular properties, with the latter still poorly understood. In this issue % h k4 N5 C& D5 N- k
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
% p, b2 ~# S3 H ]encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
, j; v. L* I% }0 a1 Wrestricted SCN neuronal subpopulations reprograms encoding of circadian time by
( `/ b/ w2 i) L2 a# V5 zthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic # g- Y, v% r! [6 x# |2 [
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
) f5 M6 S* H& \1 |& ^$ ZWestmoreland.2 q5 a8 g: J8 Y, L; ^8 s
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发表于 2013-5-23 23:46
