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Volume 78, Issue 4On the cover: Neural networks control
9 V5 {' k) H- V5 \) y! d' ]intrinsic encoding of the circadian clock. Circadian pacemaking in the
# z2 d: y5 m' o# x, o" ~/ p/ Bsuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 9 O" ?# K8 l9 e- L4 ]
intercellular properties, with the latter still poorly understood. In this issue 5 z& p. Z+ H/ |8 i6 ] ?5 K
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level 2 |1 ~- Q# A9 p" h+ n; }
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in + o( ?! L/ m3 C8 C
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
9 o! x1 D) U! v: S4 Mthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
0 |+ L+ x$ I# U/ Rconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
& Q/ G) o! ?. [* F9 {- NWestmoreland.
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发表于 2013-5-23 23:46
