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Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.
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) m$ q" ]8 ?, ~! d; dThe deepening of our understanding of normal biology has made
; F. }& ~+ A4 ~6 uit clear that stem cells have a critical role not only in the generation of complex# J. g9 U$ J1 H$ w
multicellular organisms, but also in the development of tumors. Recent
2 j5 A6 b+ @- _findings support the concept that cells with the properties of stem cells are integral
K1 h4 e3 {5 b, r: C' `to the development and perpetuation of several forms of human cancer.1-3 Eradication
& x5 Y E! w `of the stem-cell compartment of a tumor also may be essential to achieve stable,. p `4 o0 l( k; y
long-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of4 Y% S. q$ }6 k- Y$ g' q5 G% y
the properties of stem cells have made specific targeting and eradication of cancer: R( }0 u7 _' W) R# g8 m/ `
stem cells a topic of considerable interest. In this article, we discuss the properties
" F2 b. t% ^/ D# ~0 a$ pof cancer stem cells, outline initial therapeutic strategies against them, and present
. K) y; A6 k- [3 R: A' o5 |challenges for the future.( G. A& ^( |* L$ u, `: T
8 O0 S* E# _8 M+ y2 ^$ }/ d8 W附件是ｐｄｆ全文1 w" ?* l- W' B1 o# F3 J) X
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发表于 2009-3-24 11:30
发表于 2009-6-3 13:46
