Mechanisms of Disease Cancer Stem Cells

richy

Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.
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9 _  v: h) x+ YThe deepening of our understanding of normal biology has made# n3 G: N4 o, C" S% C
it clear that stem cells have a critical role not only in the generation of complex% \: J9 g" }2 g) z. d% `
multicellular organisms, but also in the development of tumors. Recent
, R4 q$ m1 A* w! xfindings support the concept that cells with the properties of stem cells are integral
% B- I1 d/ S1 k8 s' ~& _9 yto the development and perpetuation of several forms of human cancer.1-3 Eradication
: ]/ E+ l  |0 N# |4 }/ Z) u) rof the stem-cell compartment of a tumor also may be essential to achieve stable,
! K9 ~, r- b6 N2 _% Plong-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of+ V' L4 o* C2 K
the properties of stem cells have made specific targeting and eradication of cancer+ y9 c" `* k2 V  A  Z
stem cells a topic of considerable interest. In this article, we discuss the properties% I% v$ H! \- C1 I$ f: r+ x
of cancer stem cells, outline initial therapeutic strategies against them, and present
3 P7 j2 y- ~) H2 L! r( O8 ]challenges for the future.
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" Q' U' q8 S7 A( H- w附件是ｐｄｆ全文
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efool

不错，很有价值

Fischer3

好东西，要顶！

ahmusht

have a look

Chris

like it 4 X% l6 g2 U/ c& q5 A0 p
thanks

barton_nyd

好东西，看看啊

yolanda_sea

谢了

hualin840518

很好！

hualin840518

很好！谢谢诶！

15816126

good