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Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.) a2 c! b' Q- e2 S2 j3 F R
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The deepening of our understanding of normal biology has made
, v u% l" i& A6 pit clear that stem cells have a critical role not only in the generation of complex
; {5 e8 P8 t8 Q' f8 |0 tmulticellular organisms, but also in the development of tumors. Recent7 s2 H! S0 d7 y: ^4 a
findings support the concept that cells with the properties of stem cells are integral
/ a" y8 \/ h7 E" h: bto the development and perpetuation of several forms of human cancer.1-3 Eradication
: m: m0 D3 b6 Fof the stem-cell compartment of a tumor also may be essential to achieve stable,
* G" d/ y0 e7 H& j5 N, p7 q! Flong-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of- u4 h9 B4 I' N
the properties of stem cells have made specific targeting and eradication of cancer% ?+ f J1 b% \! o1 u) O& H3 t" T
stem cells a topic of considerable interest. In this article, we discuss the properties
* Z( [: H- s8 D& F; Xof cancer stem cells, outline initial therapeutic strategies against them, and present
j, a, Z+ V( n" E2 Z' n5 Lchallenges for the future.
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发表于 2009-3-24 11:30
发表于 2009-6-3 13:46
