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Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.* j8 \) m( G. [. f. X- F
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The deepening of our understanding of normal biology has made
0 K2 c. i: A( lit clear that stem cells have a critical role not only in the generation of complex% j$ u1 L o5 ~/ H6 o
multicellular organisms, but also in the development of tumors. Recent: p# N+ `* x- D
findings support the concept that cells with the properties of stem cells are integral" c8 f: T: {! ]2 [$ F
to the development and perpetuation of several forms of human cancer.1-3 Eradication$ [, Q! Z% ^2 T5 w5 A
of the stem-cell compartment of a tumor also may be essential to achieve stable,
4 D. I1 J0 F, o( u( [4 f0 xlong-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of" R$ J c1 I* y, u! k- o% o/ U9 Y/ e
the properties of stem cells have made specific targeting and eradication of cancer3 o6 }; g8 V1 V8 x E
stem cells a topic of considerable interest. In this article, we discuss the properties; b' o/ Z% ?6 ? z
of cancer stem cells, outline initial therapeutic strategies against them, and present
% ?. ~; a+ d/ ~7 ?% Ychallenges for the future.3 F: x+ p) o. d
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