|
- 积分
- 6
- 威望
- 6
- 包包
- 38
|
Josephine White1 and Stephen Dalton*,2( Y* H$ _# B+ A+ B' v
1Department of Molecular Biosciences, University of Adelaide, South Australia, 5005; and 2Department
+ z% h4 Z, |" S3 ~" p& ?- Cof Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602
3 K% t" p3 _% |. p. ^
& v) ~+ H! V' }! R# V4 `$ wAbstract
( s, _8 S! G' {+ QEmbryonic stem cells have the capacity for unlimited proliferation while retaining their, n( p \" e( X# p3 l
potential to differentiate into a wide variety of cell types. Murine, primate and human
9 z1 b& s$ X) q' s8 M& |embryonic stem cells (ESCs) exhibit a very unusual cell cycle structure, characterized( y4 R+ G% g6 s8 d$ a
by a short G1 phase and a high proportion of cells in S-phase. In the case of mESCs, this; V# X. [% B9 w" D S( ?9 g
is associated with a unique mechanism of cell cycle regulation, underpinned by the precocious( i1 q. s2 b5 a
activity of cyclin dependent protein kinase (Cdk) activities. As ES cells differentiate,
- b' A4 e1 W5 H% E2 B5 L3 Xtheir cell cycle structure changes dramatically so as to incorporate a significantly
, W% N& A# b' m$ q7 Rlonger G1 phase and their mechanism of cell cycle regulation changes to that typically$ _$ T% W* E, t# P9 s# i; g( D7 Y
seen in other mammalian cells. The unique cell cycle structure and mechanism of cell
* E; Q# |& s+ N1 |) Gcycle control indicates that the cell cycle machinery plays a role in establishment or- o1 _5 u; z6 b! R( A
maintenance of the stem cell state. This idea is supported by the frequent involvement4 Y: a; C& q, ~5 u
of cell cycle regulatory molecules in cell immortalization.
: z! ]7 W2 q8 Z" c8 pIndex Entries: ES cells; cell cycle; Cdk; pluripotent.
7 k- {: y( k3 C/ O2 m e% Y$ M! X
; G9 Y1 b' z6 {, ?% M( Z) S
Cell cycle control of embryonic stem cells.pdf
(268.19 KB)
|
|
发表于 2009-4-20 11:50
