|
- 积分
- 6
- 威望
- 6
- 包包
- 38
|
Josephine White1 and Stephen Dalton*,2
4 e$ {7 X/ o- T9 z9 d% n1Department of Molecular Biosciences, University of Adelaide, South Australia, 5005; and 2Department
0 H' e! r" J8 n4 R2 Pof Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602$ r8 Z4 Y, S7 `" b z
! N* M8 }5 j( m" R
Abstract3 ^3 S& _! o3 ^
Embryonic stem cells have the capacity for unlimited proliferation while retaining their4 c( B9 B* w) Y, n3 P
potential to differentiate into a wide variety of cell types. Murine, primate and human
3 m& j) w; ?7 j# s0 ~- ^embryonic stem cells (ESCs) exhibit a very unusual cell cycle structure, characterized
+ s! f' x1 c$ \by a short G1 phase and a high proportion of cells in S-phase. In the case of mESCs, this0 j' S; s% O& R/ S
is associated with a unique mechanism of cell cycle regulation, underpinned by the precocious$ |! d' W- ?" u4 k$ a
activity of cyclin dependent protein kinase (Cdk) activities. As ES cells differentiate,. v' m- {; H: O9 f. T5 l% R
their cell cycle structure changes dramatically so as to incorporate a significantly
; h9 U2 C& @4 v2 w3 t R5 u( ~longer G1 phase and their mechanism of cell cycle regulation changes to that typically3 r# {2 n" j" }/ F
seen in other mammalian cells. The unique cell cycle structure and mechanism of cell7 b( D, M. ~! v% j( J4 `" l+ Y
cycle control indicates that the cell cycle machinery plays a role in establishment or
& J3 L6 ?. D V% Dmaintenance of the stem cell state. This idea is supported by the frequent involvement
- e& n: {0 V" i( }of cell cycle regulatory molecules in cell immortalization.
; s( j0 v2 C5 X, NIndex Entries: ES cells; cell cycle; Cdk; pluripotent.
1 x+ }8 _1 w( h) {" i. ?, r* k: ~+ R2 ^) F) V- G8 N6 S, d0 I
Cell cycle control of embryonic stem cells.pdf
(268.19 KB)
|
|
发表于 2009-4-20 11:50
