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Josephine White1 and Stephen Dalton*,2$ _. M! G. s( V, x( m+ B
1Department of Molecular Biosciences, University of Adelaide, South Australia, 5005; and 2Department
+ \, Y9 L# s8 A: a, l. K8 a. Xof Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602) H! J# d& R; [+ H3 }
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Abstract
$ U6 N' P R, j; s' ^" P) DEmbryonic stem cells have the capacity for unlimited proliferation while retaining their
+ D( C7 N. k, r# }! u' D6 ~$ hpotential to differentiate into a wide variety of cell types. Murine, primate and human# R F/ [$ K ?- C" J
embryonic stem cells (ESCs) exhibit a very unusual cell cycle structure, characterized
& n& ^: w9 @) @: C' Aby a short G1 phase and a high proportion of cells in S-phase. In the case of mESCs, this+ n/ q' [! N8 g" }& u; t' Z y
is associated with a unique mechanism of cell cycle regulation, underpinned by the precocious
, e7 w. m9 y; K/ Z; g( Cactivity of cyclin dependent protein kinase (Cdk) activities. As ES cells differentiate,
5 `1 I. w5 u3 ltheir cell cycle structure changes dramatically so as to incorporate a significantly
. Z/ W7 O$ J, Flonger G1 phase and their mechanism of cell cycle regulation changes to that typically+ u, U6 U Q2 `" g. ?
seen in other mammalian cells. The unique cell cycle structure and mechanism of cell+ Q& o, A, n, G$ A( T
cycle control indicates that the cell cycle machinery plays a role in establishment or9 ^8 k8 A$ T# p" k6 q- i( }: U
maintenance of the stem cell state. This idea is supported by the frequent involvement
/ U6 _+ V! N' G# X6 oof cell cycle regulatory molecules in cell immortalization.
. H8 L3 `' U6 W* s4 E6 i6 BIndex Entries: ES cells; cell cycle; Cdk; pluripotent.* Y& ~0 D! Z! C# [9 E
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Cell cycle control of embryonic stem cells.pdf
(268.19 KB)
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发表于 2009-4-20 11:50
