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Cancer Res. 2013 Aug 2. [Epub ahead of print]/ K6 r* S. d6 O8 {
p63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.
! Q. d. q* V" N0 D: q1 S! c+ GPiccolo S, Enzo E, Montagner M.
+ E! v( M3 [, |. W% K$ R3 E3 |Source
" `. R6 I& H5 ?$ j, sAuthors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.) B7 q( J6 n0 g
5 C- \$ G# | u" l5 u% Q5 y+ y6 X: d" VAbstract
; y2 x& w& q* U! a, g' M3 d" e; f# lMetastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.
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PMID: 23913939 [PubMed - as supplied by publisher]) D2 }! ]5 T0 q( ]
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发表于 2013-8-8 23:25
