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本帖最后由 细胞海洋 于 2011-10-20 15:38 编辑
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王公平1,2,杨波1,关方霞3,杜英4,常克亮1,宋来君1,胡祥5,曾光伟1,2 J$ z# }. f8 q, d( v
(1.郑州大学第一附属医院神经外科,郑州450052;2.河南科技大学第一附属医院肿瘤科,. e0 J1 W4 a, n8 k( c! h
河南洛阳471003;3.郑州大学生物工程系,郑州450001;4.郑州大学基础医学院微生物
X% D% c6 q) q与免疫学教研室,郑州450052;5.深圳市北科细胞工程研究所,深圳518000)
8 |9 @' l2 ?4 i[摘要] 目的:通过不同途径移植羊膜间充质干细胞治疗脑损伤大鼠,比较脑损伤大鼠行为学的改$ j% O+ }3 G( p' R: a& W
善,为脑损伤治疗选择有效的移植途径。方法:制作80只Wistar大鼠脑损伤模型,分为对照组与治疗4 Q3 g8 _) f9 S% `$ K
组。对照组为单纯脑损伤大鼠,共20只;治疗组分为尾静脉移植组(A组)、侧脑室移植组(B组)、脑损- G2 `% O- u6 B1 \5 _* M% J
伤区移植组(C组),每组20只,均给与植入人羊膜间充质干细胞,采用NSS评分法评定治疗效果。结- p5 X# n4 U' E3 P# d4 l
果:脑损伤区移植组大鼠行为学改善与其他各组相比,差异有统计学意义(P<0.05);侧脑室移植组分7 u' v' `2 s+ Q( s
别与尾静脉移植组及对照组相比,差异有统计学意义(P<0.05);而尾静脉移植组与对照组相比,差异
/ j0 X; @5 c: W0 \1 y7 ]无统计学意义(P>0.05)。结论:脑损伤区移植羊膜间充质干细胞是治疗脑损伤大鼠的有效途径。 a* S% p5 d7 W$ n4 y4 v, d; ?, B
[关键词] 羊膜间充质干细胞; 移植; 大鼠; 脑损伤+ W L5 _' I" U6 R% O
[中图分类号] R651.65 [文献标识码] A [文章编号] 16727347(2008)10092605
7 o9 I+ S( w0 v5 G& e) bTreatmentofbraininjuredratsthroughtransplanting% e- E" l! E" u) ^3 `
amnioticderivedmesenchymalstem cellsindifferentways# c# V' A+ U! T+ Q2 b4 R2 T
WANGGongping1,2,YANGBo1,GUANFangxia3,DUYing4,CHANGKeliang1,9 T3 ]5 ~9 h6 f
SONGLaijun1,HUXiang5,ZENGGuangwei1,2
* ?' }3 e/ j0 }- T2 q0 o(1.DepartmentofNeurosurgery,FirstAffiliatedHospital,ZhengzhouUniversity,Zhengzhou450052;/ b- o3 j/ P5 e7 b Q
2.DepartmentofTumor,FirstAffiliatedHospital,HenanUniversityofScienceandTechnology,/ _/ O1 \$ w1 b& Y& H( `/ e
LuoyangHenan471003;3.DepartmentofBiomedicineandBioengineering,ZhengzhouUniversity,
' e3 ~7 x! V# n2 W4 _9 {1 WZhengzhou450001;4.DepartmentofMicrobiologyandImmunology,CollegeofBasicMedicalSciences,
9 x- b P) o8 r$ @7 t6 K$ o) dZhengzhouUniversity,Zhengzhou450052;5.ShenzhenBeikeCellEngineeringInstitute,Shenzhen518000,China)
- k" E8 n2 x/ e" Z# z: xAbstract: Objective Tocomparethebehavioralimprovementtofindthebesttransplantation& \* X( N1 r* |9 {$ m
approachfortreatingbraininjurythroughtransplantingamnioticderivedmesenchymalstem cellsinto
1 M( ]0 F: l- ^braininjuredratsindifferentways.Methods EightybraininjuredWistaratswererandomlydivided
- h" Q- Z6 f2 j7 T* u2 Dintoacontrolgroupwithbraininjuryalone(n=20)andatreatmentgroup(n=60)whichwere
0 W# K# X7 M1 p, UfurtherevenlydividedintoGroupA(transplantedthroughthevenacaudalis),GroupB(transplanted- U2 X& H0 \$ K9 w2 @ k+ W
throughtheventriculuscerebrilateralis), andGroupC (transplantedthroughtheinjuredbrain6 H$ A5 t4 d8 Z' j+ \# J! D
area).Eachgroupwastransplantedwithamnioticderivedesenchymalstemcells,andtheirtherapeu. ] h8 q) ]0 u% X- k# K3 b
ticefficacywouldbeevaluatedthroughtheneurologicalseverityscore(NSS).Results Compared withothergroups,thebehaviorsofGroupChadmarkedlyimproved.Therewasstatisticallysignifi# \8 N% T' b3 V
cantdifferenceinthe2groups(P<0.05).Comparedwiththecontrolgroup,thebehaviorsof
: C( K5 h s* \* S0 xGroupAandGroupBhadmarkedimprovement.Therewasstatisticallysignificantdifferenceinthe3
8 i' V7 e; p7 h* g7 Ogroups(P<0.05).However,therewasnosignificantdifferencebetweenGroupAandthecontrol9 f8 C, b0 x7 g4 ^' C
group(P>0.05).Conclusion Transplantingtheamnioticderivedmesenchymalstemcellsintothe
4 A' u- T# G8 h$ F: Y/ I4 Vinjuredbrainareamaybeeffectiveforbraininjuryinrats.* o& h8 {' Y# x9 M
Keywords: amnioticderivedmesenchymal; stem cell; transplantation; rats; brain0 p8 U7 O: D2 t! G6 `3 o+ H, o& E
injury) o9 L3 ]6 b9 K9 _
[JCentSouthUniv(MedSci),2008,33(10):092605]
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