《细胞》[cell]2010年8月20出版pdf全文

scienese

4 j) R$ X* D& j# f

/ b" O- B7 i# f- S
$ R& [1 N* S  z5 n0 Z. p
& {3 q( r# ?$ K, i9 \! u, n) d封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.
6 \5 S+ G; j% o+ I4 A8 ~# a- Q" q, i9 o 好可爱的小鼠O(∩_∩)O哈，超喜欢~~3 V, \- [8 A: g$ I& |
9 w4 i5 S) g8 Z
Leading Edge
0 g* |+ _! e5 R( ~8 I3 G% u4 oIn This Issue p497
5 S. Q# ?: ?3 Q) W2 Q* k2 ^Full Text | PDF (273 kb)- o+ }. ]6 O: I
Cell Culture p501
3 r. K  `1 Z/ T' I- N' r" WSummary | Full Text | PDF (258 kb)
0 @' k$ P! v) xEssay
8 g: _9 ^0 }5 L5 P9 z, F* k5 I) Y8 t+ q, r7 E4 G" K3 w
Induced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507' j7 \3 @) R5 P9 |) [
Ludger Johannes, Satyajit Mayor2 G. V% z3 S9 @
Summary | Full Text | PDF (450 kb)- w- J; F0 z; [5 M
Previews  @6 u* D8 I$ K8 O7 O
' C0 e# m3 ~) n7 ]
Reversing Cachexia p511( _* y) m' B& G  N
Michael J. Tisdale8 N* z7 y& y9 C" b+ W# b& b
Summary | Full Text | PDF (345 kb)- h5 Q8 F. n, [3 X4 a6 Z6 T2 l  ?
The Ins and Outs of EGFR Asymmetry p513: D. `( V# s, J1 u& Z1 {  M
Daniel J. Leahy
: D8 k. A- S' F* L" ]Summary | Full Text | PDF (324 kb)4 }' j# T2 y$ T9 Q5 I+ L( b  }
Up a Hydrophobic Creek with a Short Paddle p515% o8 t  ?; o$ `( w2 M0 @% x; d
Raymond E. Hulse, Qufei Li, Eduardo Perozo$ q7 v' ]9 w- M1 W/ v" u
Summary | Full Text | PDF (218 kb)
8 D  X* h% @* Z1 k# ]% S$ I8 v2 pThe Immunoproteasome Cleans up after Inflammation p517
5 p. E% Z' L- R9 {$ \9 K3 E5 |Sjoerd van Deventer, Jacques Neefjes. s- J3 M3 A1 u
Summary | Full Text | PDF (205 kb)
3 V) k. h( h! t9 rReview1 s: ?, F, V. a

* i/ z. V( d5 m, {9 r% j' R7 V. dFeatured Article4 g" r1 A1 u9 r* {9 j4 @- T
Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p5192 x1 P# ~2 Q, `4 Y2 t6 Z
Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker- u0 |) S6 s# e. j  D1 ?' Y1 c
Summary | Full Text | PDF (1484 kb) | Supplemental Data
9 `! L+ e. A% q4 l1 e  DArticles" G# U( O7 k/ O* u- v( ~9 Q
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p531# b+ F; S0 F0 n( A6 x$ w% r
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
  E$ Y' _, |: {( ~1 mSummary | Full Text3 f2 S! {+ V' m) {/ x
PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p544+ o  t3 T5 O( J2 r) K/ ^
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
/ K- M3 I+ d1 i* Q& |$ a  ZSummary | Full Text
2 M8 i7 G! |, A4 AThe Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556
* T* M) Z9 h6 E' \Kevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison
0 J  O- v; w9 ?; ]; VSummary | Full Text0 t/ [- ^- N& K8 ~/ w
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p568
4 ]3 Q) e' y" T4 eDiego Alvarado, Daryl E. Klein, Mark A. Lemmon
9 ?: H0 s/ t4 v" s+ GSummary | Full Text
5 \0 g; l8 _3 t6 h! d" ]A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580
  S: a1 `; \& |8 M8 wYanping Xu, Yajamana Ramu, Zhe Lu6 g5 T$ S; D* N6 Y! {9 n
Summary | Full Text
1 h) H& t# Z" a2 n+ WATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p590
; @+ u' ]5 Z8 Y5 y1 ?' ^$ iLilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
4 H( l" k% U% |0 {; y$ |4 ]+ V7 x1 s# {Summary | Full Text
0 x% q6 p4 Q5 q6 L# t+ j# dIdentification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p601
8 b! y& W6 h4 BTjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen) J+ l+ U- U; e  ?$ N2 R7 @) r
Summary | Full Text
( V! N+ C: i' a$ F3 @7 A# BImmunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p6133 e: b, K9 T: @4 D
Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger  k% D  H' N) K3 W' Y  k
Summary | Full Text
  y) N: w9 _& m4 v9 ]* A: J) wAn Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p625
0 P  l& X' W+ pMichael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
- A3 C8 I/ g5 nSummary | Full Text
' b5 g* j' Q/ l* g8 jResource! e! p% |+ Z/ f
Featured Article6 }$ J4 E" y0 ], H/ j5 f
Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p6375 L1 P2 E1 D9 K0 n' `
Daniel C. Gray, Sami Mahrus, James A. Wells( `- ?1 p: J3 ?; L7 T% D
Summary | Full Text
* t' m  y  q7 k  G4 H* G) T+ E" fSnapShot: x) J9 {9 K- a% ^; g9 X+ w
SnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e11 D' s  U) r3 m
Gerard Mazón, Eleni P. Mimitou, Lorraine S. Symington( m4 w- R3 f. g' S0 L
PDF (1491 kb)
  t3 v( P: f+ o* u8 D5 V想看赶紧下哦，呵呵4 Y; A7 x! O( b3 {& ~) S) o

1 @- X$ s" h% n) y$ d[hide][/hide]

张也行

哈哈 谢谢分享

baixueyao029

谢谢分享

军医

谢谢啊

aehxing

回复 1# scienese

mckf111

太谢谢

initiation

谢谢！

懵懂干细胞

谢谢分享

豆腐干

好好学习，天天向上

susannajoke

谢谢！