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本帖最后由 细胞海洋 于 2011-1-9 21:53 编辑
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4 r& W( u7 Y; O. _' g7 uProgenitor Cell Therapy for Neurological Injury
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Severe neurological injury, including traumatic brain injury, spinal cord injury, and) w6 x0 ^8 K# [0 V. R
stroke, can have devastating consequences. There are currently no reparative therapies \6 c2 }7 p; l. o8 t4 b
for neurological injury, with most treatments designed to limit secondary damage.' X3 ]' F3 K p0 z9 T
The idea that exogenous stem and progenitor cells have the potential to
- \9 \0 \2 t2 h: I" x5 _promote a reparative response to injury is now supported by pre-clinical data,
1 F: m* k; E' a2 P' m" X5 D& x; rprompting early translational studies using progenitor cell therapies. To that end, `8 F m" a K1 U
this text explores the unique aspects of neurological injury and focuses on the critical2 G1 U! J, b0 i7 A
translational issues of cell delivery: routes of administration, types of progenitor
5 S" V8 a( z U7 }1 vcells (alone and/or in combination), timing of delivery, and adjuncts to promote cell/ r9 t7 p! h+ W# ^; |
engraftment/survival/effectiveness. Finally, measuring the effects of transplanted
8 t: }" G1 c9 xcells and cell tracking is explored in several chapters.' x2 ` \1 Z3 Z: r! R
Even while compiling this monograph, the paradigms of how cell-based therapeutics( C! m5 }; M3 w: V. i/ d! v; L9 w! k
affect neurological injury have been changing. Mechanisms that seemed5 k; d( u' l2 U' }, I
reasonable and well-supported are being re-examined, and this necessarily drives
7 x( E0 w9 W* k& d3 sthe movement toward various clinical trial plans. The earliest clinical trials are# J2 m7 B, ]8 z+ k
beginning, and as this monograph goes to press, Phase 2 studies in TBI and stroke
/ G0 V: ~0 V/ W9 rwill begin. The developments in the field may ultimately offer realistic hope for
2 i8 S- ~8 d! W2 \2 M1 d0 D4 B5 Pimprovement in patients with severe injuries, and the work on these vexing problems
* F% c& h( S5 L( b* I' rwill be the key to unlocking future treatments.. o- T6 M# U4 ?$ I& I' p' h
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发表于 2011-1-3 15:13
