请问Transit-amplifying cells 到底是什么意思

ycjzyh

     在文献中看到这样一段话 In some tumors, normal tissue stem cells may serve as the cells-of-origin that undergo oncogenic transformation to yield CSCs; in others, partially differentiated transit-amplifying cells, also termed progenitor cells, may suffer the initial oncogenic transformation thereafter assuming more stem-like character.
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4 B! m+ c% C. x& g+ p$ h    这里好像说Transit-amplifying cells 是祖细胞，在网上查了好久。5 {/ b$ ?: ~6 k3 g6 s! V
    有一篇文献《隐窝干细胞和结肠癌的发生》中说是“子代中有少量的传递- 放大细胞(transit-amplifying cell, TA)，TA细胞具有非常有限的分裂和自我更新能力，大约经过3 － 4 次分裂，通过一个位于隐窝中低部的传递-放大区域(transitamplifying zone)向上迁移，最后到达肠腔面。”
3 s5 G8 O" \4 `8 A: N: G9 y    而另一篇文献《肠上皮干细胞分裂、分化的信号转导机制》中说“肠上皮干细胞的不对称分裂就是一个干细胞和一个子代细胞(daughter cel1)，其中干细胞可以维持自身数量的恒定，而子代细胞继续分化为“过渡扩增细胞”(transit．amplifying cell，TA)。TA可以认为是多能细胞，正常情况下不具有干细胞的特性，因为它们将继续朝着各个方向分化，最终分化为分泌性细胞(包括杯状细胞、潘氏细胞、内分泌细胞)和吸收细胞，最后走上凋亡的道路。但肠上皮干细胞受到损伤的情况下TA会向隐窝底部迁移．恢复成为肠上皮干细胞。
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    求正解！是否真是祖细胞？

grape

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以下是"Adult stem and transit-amplifying cell location. Histol Histopathol. 2006 Sep;21(9):995-1027"一文对Transit-amplifying cells (TAC)的解释：
7 Q8 C- ~: d- c+ C+ fTransit-amplifying cells (TAC) are committed progenitors among the Adult stem cells (ASC) and their terminally differentiated daughter cells.3 ^1 j/ d2 s5 C% Q) T
“过渡-扩增细胞（Transit-amplifying cells,TAC）”被认为是介于成体干细胞（Adult stem cells, ASC) 与其终末分化子细胞（terminally differentiated daughter cells）之间的一类祖细胞（progenitors）（或前体细胞）。2 E. m& @1 `5 M1 c
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个人认为该细胞被命名为"Transit-amplifying cells"正是取"过渡、介于"之意，the cell have a transitional amplifying ability.& x$ ^* i: ?  m, c1 V  J

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源自
2 U' O! X: T5 z7 Q5 _. B3 tHistol Histopathol. 2006 Sep;21(9):995-1027.
* D+ d( H6 N0 _! }; d/ _& `! OAdult stem and transit-amplifying cell location.8 X$ ^5 u+ n1 \/ W( k
Díaz-Flores L Jr, Madrid JF, Gutiérrez R, Varela H, Valladares F, Alvarez-Argüelles H, Díaz-Flores L.( l8 x  K5 w1 |/ d" e/ F9 y
SourceDeparment of Pathology, Histology and Radiology, School of Medicine, La Laguna University, Canary Islands, Spain.5 Z+ [. C3 x7 Y2 u: z; F3 X

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* m2 Q3 N9 ^. E4 o& K" g; WAdult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be useful to regenerative medicine and tissue engineering.  The ASC reside in a specialized physical location named niche, which constitutes a three-dimensional microenviroment where ASC and TAC are protected and controlled in their self-renewing capacity and differentiation. The niche can be located near or far from the recruitment point, requiring a short or long-distance cellular migration, respectively. This paper briefly reviews the current status of research about ASC plasticity, transdifferentiation, fusion and functional adaptation mechanisms. Subsequently, ASC and TAC occurrence, characteristics and location have been considered in the skin, cornea, respiratory tract, teeth, gastrointestinal tract, liver, pancreas, salivary glands, kidney, breast, prostate, endometrium, mesenchyma, bone marrow, skeletal and cardiac muscle, nervous system and pituitary gland. Moreover, the role of cancer ASC has also been revised.
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PMID:16763950[PubMed - indexed for MEDLINE] ' @$ d; ~3 J1 ~$ E9 C9 I
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Adult stem and transitamplifying cell location.pdf (2.9 MB)

2011-8-25 08:05 上传

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ljs

这个问题问的好，我也不太明白这个词是什么意思？

饶冠华

而子代细胞继续分化为“过渡扩增细胞”(transit．amplifying cell，TA)。这个是正确的  一般过渡扩增的细胞只是在特定生理条件诱导下才会短时间存在的  至于是不是就等价于祖细胞  这个概念显然不能等同， transit amplifying cell 是从增殖时效角度来命名的概念，而祖细胞是从分化角度命名的概念  两者有交集 但不能等同 理解任何概念的时候都首先要记住对应的名词是从什么方面命名的

bin

我也正在纠结这个问题，学习了。

gandanxiaoyang

在肝脏和肠道系统这个名词好像经常使用。我的理解是：这群细胞介于干细胞和成熟分化细胞之间，是一种来源于干细胞，具有干性的低分化细胞亚群。也可以认为是一种过渡细胞类型。

451991494

我正在纠结这个名词，现在明朗了好多，谢谢