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1 Krampera M, Glennie S, Dyaon J,et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide. Blood, 2003;101:3722-3729* F; G: m7 q) F {7 T" o, q
2 Potian JA, Aviv H, Ponzio NM, et al. Vetolike activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol, 2003;171:3426-3434
& x, D9 e/ B+ z3 Klyushnenkova E, Mosca JD, Zernetkina V, et al. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. J Biomed Sci, 2005;12:47-577 e/ O5 J& m8 i' `! b7 m8 d7 Q
, O- ~6 S& {1 J% D2 F" Z4 DiNicola M, CarloStella C, Magni M, et al. Human bone marrow stromal cells suppress Tlymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 2002;99:3838-3843
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4 `6 }4 B/ `3 _+ \2 \ I& L, y5 Rasmusson I, Ringden O, Sundberg B, et al. Mesenchymal stem cells inhibit lymphocyte proliferation by mitrogens and alloantigens by different mechanisms. Exp Cell Res, 2005; 305:33-41* t! B% H! ^5 v/ w: @) H. F
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6 Sun S,Guo Z,Xiao X,et al. Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method. Stem Cell, 2003;21:527-535- \/ z3 P; J! S+ x( N0 d; Q
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7 Maccario R, Podesta M, Moretta A, et al. Interaction of human mesenchymal stem cells with cells involved in alloantigenspecific immune response favors the differentiation of CD4 Tcell subsets expressing a regulatory/suppressive phenotype. Haematologica, 2005;90:516-525
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8 Djouad F, Plence P, Bony C, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood, 2003;102: 3837-3844
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9 Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell response. Blood, 2005; 105:1815-1822
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3 I- B' _! x6 K5 Z* D! I. O10 Beyth S, Borovsk Z, Mevorach D,et al. Human mesenchymal stem cells alter antigen presenting cell maturation and induce Tcell unresponsiveness. Blood, 2005; 105:2214-2219; k/ c4 k- T4 o+ F; w1 D
' z" J0 z) m/ p( D8 A8 }7 w- _/ q11 Jiang XX, Zhang Y, Liu B, et al. Human mesenchymal stem cells inhibit differentiation and function of monocytederived dentritic cells. Blood, 2005; 105; 4120-4126 h* ~5 j* W/ f. Z2 E& j F& w
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12 Nauta AJ, Kruisselbrink AB, Lurvink E, et al. Mesenchymal stem cells inhibit generation and function of both CD34 derived and monocytederived dendritic cells. J Immunol, 2006; 177: 2080-2087
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* d; ~. U% W9 f5 Z8 [: z3 P; }13 Rasmusson I, Ringden O, Sundberg B, et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation, 2003; 76 :1208-1213
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14 Angoulvant D, Clerc A, Benchalal S, et al. Human mesenchymal stem cells suppress induction of cytotoxic response to alloantigens. Biorheology, 2004; 41:469-476& O6 W$ t; i) J$ q/ L6 G
8 {+ [7 E- j' Z9 P15 Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol, 2002; 30: 42-48+ }; g8 i; p. e2 n8 ` b+ S; S
9 S2 i& X" j; A% l! a16 Guo Z, Li H, Li X, et al. In vitro characteristics and in vivo immunosuppressive activity of compact bonederived murine mesenchymal progenitor cells. Stem Cells,2006; 24: 992-1000
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17 Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T cell anergy. Blood, 2005; 106: 1755-1761+ t+ ~0 H3 H' u, K: m
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18 Lazarus HM, Haynesworth SE, Gerson SL, et al. Ex vivo expansion and subsequent infusion of human bone marrowderived stromal progenitor cells (mesenchymal stem cells): implication for therapeutic use. Bone Marrow Transplant, 1995; 16: 557-5649 v: r" O6 Y+ ]
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19 Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLAidentical sibling cultureexpanded mesenchymal stem cells and hematopioetic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant, 2005; 11:389-398
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20 Lee ST, Jang JH, Cheong JW, et al. Treatment of highrisk acute myelogenous leukemia by myeloablative chemoradiotherapy followed by coinfusion of T celldepleted haematopioetic stem cells and cultureexpanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype. Br J Haematol, 2002; 118:1128-1131
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21 LeBlanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graftversushost disease with third party haploidentical mesenchymal stem cells. Lancet, 2004; 363(9419):1439-1411
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